Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, United States.
J Neuroimmunol. 2010 Feb 26;219(1-2):25-32. doi: 10.1016/j.jneuroim.2009.11.010. Epub 2009 Dec 8.
C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation. WD consumption resulted in significantly increased body weight and astrocyte reactivity, but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL increased body weight, and impaired cognition, increased brain inflammation, and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation.
C57Bl/6 小鼠给予高脂肪西方饮食（WD，41%脂肪）或高脂肪猪油饮食（HFL，60%脂肪），并使用石 T 迷宫评估认知能力和脑炎症的生化标志物。WD 摄入导致体重显著增加和星形胶质细胞反应性增强，但认知功能不受损害、小胶质细胞反应性或细胞因子水平升高不受影响。HFL 增加体重，损害认知功能，增加脑炎症，降低 BDNF。总的来说，这些数据表明，虽然不同的饮食配方可以增加体重，但高脂肪饮食破坏认知的能力与脑炎症有关。
