MRC Epidemiology Resource Centre, University of Southampton, UK.
Age Ageing. 2010 Mar;39(2):197-203. doi: 10.1093/ageing/afp204. Epub 2009 Dec 8.
frailty, a multi-dimensional geriatric syndrome, confers a high risk for falls, disability, hospitalisation and mortality. The prevalence and correlates of frailty in the UK are unknown.
frailty, defined by Fried, was examined among community-dwelling young-old (64-74 years) men (n = 320) and women (n = 318) who participated in the Hertfordshire Cohort Study, UK.
the prevalence of frailty was 8.5% among women and 4.1% among men (P = 0.02). Among men, older age (P = 0.009), younger age of leaving education (P = 0.05), not owning/mortgaging one's home (odds ratio [OR] for frailty 3.45 [95% confidence interval {CI} 1.01-11.81], P = 0.05, in comparison with owner/mortgage occupiers) and reduced car availability (OR for frailty 3.57 per unit decrease in number of cars available [95% CI 1.32, 10.0], P = 0.01) were associated with increased odds of frailty. Among women, not owning/mortgaging one's home (P = 0.02) was associated with frailty. With the exception of car availability among men (P = 0.03), all associations were non-significant (P > 0.05) after adjustment for co-morbidity.
frailty is not uncommon even among community-dwelling young-old men and women in the UK. There are social inequalities in frailty which appear to be mediated by co-morbidity.
衰弱是一种多维老年综合征,会增加跌倒、残疾、住院和死亡的风险。衰弱在英国的流行程度和相关因素尚不清楚。
在英国,弗里德(Fried)定义的衰弱,在参与赫特福德郡队列研究的社区居住的年轻老年人(64-74 岁)男性(n=320)和女性(n=318)中进行了检查。
女性衰弱的患病率为 8.5%,男性为 4.1%(P=0.02)。在男性中,年龄较大(P=0.009)、受教育年龄较小(P=0.05)、没有/抵押自有住房(衰弱的优势比[OR]为 3.45[95%置信区间{CI}为 1.01-11.81],P=0.05,与自有/抵押贷款居住者相比)和汽车可用性降低(每减少一辆可用汽车,衰弱的 OR 增加 3.57[95%CI 1.32-10.0],P=0.01)与衰弱的几率增加相关。在女性中,没有/抵押自有住房(P=0.02)与衰弱相关。除了男性的汽车可用性(P=0.03)外,所有关联在调整合并症后均无统计学意义(P>0.05)。
即使在英国的社区居住的年轻老年人中,衰弱也并不罕见。衰弱存在社会不平等现象,似乎是由合并症介导的。