以显著升高的 IgE 为表现的霍奇金淋巴瘤：一例报告。
Hodgkin's lymphoma presenting with markedly elevated IgE: a case report.
机构信息
Division of Clinical Immunology & Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.
出版信息
Allergy Asthma Clin Immunol. 2009 Dec 7;5(1):12. doi: 10.1186/1710-1492-5-12.
BACKGROUND
Markedly elevated IgE as a manifestation of a lymphoproliferative disorder has been only rarely reported.
CASE PRESENTATION
We present the case of a 22 year old female referred to the adult Allergy & Clinical Immunology clinic for an extremely elevated IgE level, eventually diagnosed with Hodgkin's lymphoma. She had no history of atopy, recurrent infections, eczema or periodontal disease; stool was negative for ova & parasites. Chest X-ray revealed large bilateral anterior mediastinal masses that demonstrated prominent uptake on gallium scan. Mediastinal lymph node biopsy was consistent with Hodgkin's lymphoma, nodular sclerosing subtype, grade I/II.
CONCLUSION
Although uncommon, markedly elevated IgE may be a manifestation of a malignant process, most notably both Hodgkin's and Non-Hodgkin's lymphomas. This diagnosis should be considered in evaluating an otherwise unexplained elevation of IgE.
背景
以 IgE 显著升高为表现的淋巴增生性疾病极为罕见。
病例介绍
我们报告了一例 22 岁女性，因 IgE 水平极高而被转至成人过敏与临床免疫学门诊，最终诊断为霍奇金淋巴瘤。该患者无特应性疾病、反复感染、湿疹或牙周病病史；粪便寄生虫卵检查阴性。胸部 X 线显示双侧巨大前纵隔肿块，锝扫描显示明显摄取。纵隔淋巴结活检符合霍奇金淋巴瘤，结节性硬化型，Ⅰ/Ⅱ级。
结论
虽然不常见，但 IgE 显著升高可能是恶性过程的表现，尤其是霍奇金和非霍奇金淋巴瘤。在评估其他原因不明的 IgE 升高时，应考虑这一诊断。
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