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分娩时进行干细胞移植。

Stem cell transplants at childbirth.

机构信息

Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.

出版信息

Stem Cell Rev Rep. 2010 Mar;6(1):27-30. doi: 10.1007/s12015-009-9108-7.

DOI:10.1007/s12015-009-9108-7
PMID:20020331
Abstract

Autologous transplantation of stem cells is a natural phenomenon at birth in mammals via the umbilical cord. Here, we discuss that a delay in the cord clamping may increase stem cell supply to the baby, thereby allowing an innate stem cell therapy that can render acute benefits in the case of neonatal disease, as well as long-term benefits against age-related diseases.

摘要

自体干细胞移植是哺乳动物在出生时通过脐带的一种自然现象。在这里,我们讨论了延迟脐带夹闭可能会增加婴儿的干细胞供应,从而允许进行先天的干细胞治疗,在新生儿疾病的情况下可以带来急性益处,以及针对与年龄相关的疾病的长期益处。

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Stem cell transplants at childbirth.分娩时进行干细胞移植。
Stem Cell Rev Rep. 2010 Mar;6(1):27-30. doi: 10.1007/s12015-009-9108-7.
2
Wait a minute? An observational cohort study comparing iron stores in healthy Swedish infants at 4 months of age after 10-, 60- and 180-second umbilical cord clamping.等一下?一项观察性队列研究,比较了健康瑞典婴儿在出生后分别进行10秒、60秒和180秒脐带结扎后4个月时的铁储备情况。
BMJ Open. 2017 Dec 29;7(12):e017215. doi: 10.1136/bmjopen-2017-017215.
3
Timing of cord clamping revisited.脐带结扎时机再探讨。
J Perinat Med. 2006;34(4):293-7. doi: 10.1515/JPM.2006.056.
4
Mankind's first natural stem cell transplant.人类首例自然干细胞移植。
J Cell Mol Med. 2010 Mar;14(3):488-95. doi: 10.1111/j.1582-4934.2010.01029.x. Epub 2010 Feb 5.
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Timing of umbilical cord clamping after birth for optimizing placental transfusion.出生后脐带夹闭时机以优化胎盘输血。
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Baby-directed umbilical cord clamping: A feasibility study.婴儿导向脐带夹闭:一项可行性研究。
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Treating childhood traumatic brain injury with autologous stem cell therapy.

本文引用的文献

1
Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts.甘露醇促进神经生长因子上调和人脐带来源的造血细胞移植治疗新生大鼠缺氧缺血性脑损伤的行为学恢复。
J Cell Mol Med. 2010 Apr;14(4):914-21. doi: 10.1111/j.1582-4934.2008.00671.x.
2
Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis.人脐带血来源的祖细胞/干细胞的体外纳米纤维扩增和基因修饰可增强血管生成。
Cell Transplant. 2009;18(3):305-18. doi: 10.3727/096368909788534870.
3
Human umbilical cord blood cell grafts for brain ischemia.
采用自体干细胞疗法治疗儿童创伤性脑损伤。
Expert Opin Biol Ther. 2018 May;18(5):515-524. doi: 10.1080/14712598.2018.1439473. Epub 2018 Feb 15.
4
Evaluation of Introduction of a Delayed Cord Clamping Protocol for Premature Neonates in a High-Volume Maternity Center.在一家高流量产科中心对早产新生儿实施延迟脐带结扎方案的评估。
Obstet Gynecol. 2017 May;129(5):835-843. doi: 10.1097/AOG.0000000000001987.
5
Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping.通过延迟脐带结扎增强新生儿内源性干细胞。
Neural Regen Res. 2015 Sep;10(9):1359-62. doi: 10.4103/1673-5374.165218.
6
Cryopreservation effects on Wharton's Jelly Stem Cells proteome.冻存对牙髓干细胞蛋白质组的影响。
Stem Cell Rev Rep. 2014 Jun;10(3):429-46. doi: 10.1007/s12015-014-9501-8.
7
Baby STEPS: a giant leap for cell therapy in neonatal brain injury.婴儿 STEPS:新生儿脑损伤细胞治疗的巨大飞跃。
Pediatr Res. 2011 Jul;70(1):3-9. doi: 10.1203/PDR.0b013e31821d0d00.
8
The proliferation and differentiation of stem cell journals.干细胞期刊的增殖与分化。
Stem Cell Rev Rep. 2010 Dec;6(4):497-9. doi: 10.1007/s12015-010-9181-y.
人脐带血细胞移植治疗脑缺血。
Cell Transplant. 2009;18(9):985-98. doi: 10.3727/096368909X471279. Epub 2009 Apr 29.
4
Human cord blood CD133+ stem cells transplanted to nod-scid mice provide conditions for regeneration of olfactory neuroepithelium after permanent damage induced by dichlobenil.移植到无胸腺裸鼠体内的人脐带血CD133+干细胞为二氯苯腈诱导的永久性损伤后嗅神经上皮的再生提供了条件。
Stem Cells. 2009 Apr;27(4):825-35. doi: 10.1002/stem.11.
5
Cell therapy for stroke: remaining issues to address before embarking on clinical trials.中风的细胞治疗:开展临床试验前有待解决的遗留问题。
Stroke. 2009 Mar;40(3 Suppl):S146-8. doi: 10.1161/STROKEAHA.108.533091. Epub 2008 Dec 8.
6
Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes.足月儿脐带结扎时机对母婴结局的影响。
Cochrane Database Syst Rev. 2008 Apr 16(2):CD004074. doi: 10.1002/14651858.CD004074.pub2.
7
A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short-term clinical and laboratory endpoints.一项比较早产儿脐带即刻结扎与延迟结扎的随机临床试验:短期临床和实验室终点指标
Transfusion. 2008 Apr;48(4):658-65. doi: 10.1111/j.1537-2995.2007.01589.x. Epub 2008 Jan 10.
8
Multipotent stem cells from umbilical cord: cord is richer than blood!来自脐带的多能干细胞:脐带比血液更具优势!
Stem Cells. 2008 Jan;26(1):146-50. doi: 10.1634/stemcells.2007-0381. Epub 2007 Oct 11.
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A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants.对早产儿脐带延迟结扎时间短暂的系统评价和荟萃分析。
Neonatology. 2008;93(2):138-44. doi: 10.1159/000108764. Epub 2007 Sep 21.
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Neural stem cells for Parkinson's disease: to protect and repair.用于帕金森病的神经干细胞:保护与修复
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11869-70. doi: 10.1073/pnas.0704704104. Epub 2007 Jul 9.