Department of Nanoengineering, 9500 Gilman Drive M/C 0448, University of California San Diego, La Jolla, California 92093-0448, USA.
Nat Nanotechnol. 2010 Feb;5(2):121-6. doi: 10.1038/nnano.2009.450. Epub 2009 Dec 20.
The development of nanoscale electronic and photonic devices will require a combination of the high throughput of lithographic patterning and the high resolution and chemical precision afforded by self-assembly. However, the incorporation of nanomaterials with dimensions of less than 10 nm into functional devices has been hindered by the disparity between their size and the 100 nm feature sizes that can be routinely generated by lithography. Biomolecules offer a bridge between the two size regimes, with sub-10 nm dimensions, synthetic flexibility and a capability for self-recognition. Here, we report the directed assembly of 5-nm gold particles into large-area, spatially ordered, two-dimensional arrays through the site-selective deposition of mesoscopic DNA origami onto lithographically patterned substrates and the precise binding of gold nanocrystals to each DNA structure. We show organization with registry both within an individual DNA template and between components on neighbouring DNA origami, expanding the generality of this method towards many types of patterns and sizes.
纳米尺度电子和光子器件的发展将需要结合光刻图形的高通量和自组装提供的高分辨率和化学精度。然而，由于纳米材料的尺寸小于 10nm，而常规光刻技术可以生成的特征尺寸为 100nm，因此将其纳入功能器件一直受到阻碍。生物分子在这两个尺寸范围之间提供了桥梁，具有亚 10nm 的尺寸、合成灵活性和自我识别能力。在这里，我们通过将介观 DNA 折纸选择性地沉积在光刻图案化的基底上，并精确地将金纳米晶体结合到每个 DNA 结构上，报告了将 5nm 金颗粒定向组装成大面积、空间有序的二维阵列。我们展示了在单个 DNA 模板内以及在相邻 DNA 折纸之间的组件之间的有序组织，从而将该方法的通用性扩展到许多类型的图案和尺寸。
