State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China.
Analyst. 2010 Jan;135(1):21-7. doi: 10.1039/b911883g. Epub 2009 Nov 17.
Successful development of ultrasensitive constructs for bioimaging and biosensing is a challenging task. Recently, viruses have drawn increasing attention due to their exquisite three-dimensional structures and unique properties, including multivalency, orthogonal reactivities, and responsiveness to genetic modifications. With such well-characterized structures, functional units, such as imaging and binding motifs, can be engineered on the surface of viruses in a programmable, polyvalent manner, which leads to novel nanosized sensing/imaging systems with enhanced signaling and targeting performance. This review highlights some recent progress in the applications of viruses in bioimaging and biosensing.
成功开发用于生物成像和生物传感的超灵敏构建体是一项具有挑战性的任务。最近，由于病毒具有精致的三维结构和独特的性质，包括多价性、正交反应性和对遗传修饰的响应性，因此引起了越来越多的关注。由于具有如此良好表征的结构，可以以可编程、多价的方式在病毒表面工程化诸如成像和结合基序等功能单元，从而导致具有增强的信号转导和靶向性能的新型纳米级传感/成像系统。本综述重点介绍了病毒在生物成像和生物传感中的一些最新应用进展。
