Donnellan Kimberly A, Pitman Karen T, Cannon C Ron, Replogle William H, Simmons Jon D
Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA.
Arch Otolaryngol Head Neck Surg. 2009 Dec;135(12):1196-8. doi: 10.1001/archoto.2009.167.
To determine whether nerve integrity monitor testing during thyroidectomy predicts recurrent laryngeal nerve (RLN) function after surgery.
Prospective cohort outcomes study
The study included 210 consecutive patients with thyroid abnormalities who underwent thyroidectomy.
All patients were intraoperatively monitored with a nerve integrity monitoring system (Xomed NIM II; Medtronic Inc, Fridley, Minnesota), and their vocal cord function was assessed with fiberoptic laryngoscopy before and after surgery. Normal and impaired vocal cord function were compared using an independent t test with respect to postoperative vocal cord mobility, length of the RLN dissection, and the minimum stimulus needed to generate a response at the completion of surgery.
There was a statistically significant difference between the stimulus in milliamperes required to stimulate normal vs abnormal functioning nerves at the completion of the procedure at the cricoarytenoid joint (P = .02) and at the distal end of the RLN dissection (P < .01). A greater length of dissected nerve was associated with normal vocal cord function; however, it was not statistically significant (P = .07).
These data suggest that an RLN that responds at lower-intensity stimulation (</=0.5 mA) at the end of thyroid surgery is associated with normal vocal cord mobility.
确定甲状腺切除术中神经完整性监测测试能否预测术后喉返神经(RLN)功能。
前瞻性队列结局研究
该研究纳入了210例连续接受甲状腺切除术的甲状腺异常患者。
所有患者术中均使用神经完整性监测系统(Xomed NIM II;美敦力公司,弗里德利,明尼苏达州)进行监测,并在手术前后通过纤维喉镜评估其声带功能。使用独立t检验比较正常和受损声带功能在术后声带活动度、RLN解剖长度以及手术结束时产生反应所需的最小刺激方面的差异。
在环状软骨杓状软骨关节处(P = 0.02)和RLN解剖远端(P < 0.01),手术结束时刺激正常与异常功能神经所需的毫安数刺激之间存在统计学显著差异。解剖神经长度越长与声带功能正常相关;然而,差异无统计学意义(P = 0.07)。
这些数据表明,甲状腺手术结束时对较低强度刺激(≤0.5 mA)有反应的RLN与声带正常活动度相关。