Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
J Med Food. 2009 Dec;12(6):1268-73. doi: 10.1089/jmf.2008.0197.
The anti-ulcer potentials of aqueous (AE) and methanol (ME) extracts of whole unripe Carica papaya fruit were evaluated using ethanol- and indomethacin-induced gastric ulcer models in rats. The effect of the extracts on small intestinal propulsion was also investigated. The extracts significantly reduced the ulcer index in both experimental models (P < .05) compared to the control group. ME showed a better protection against indomethacin-induced ulcers, whereas AE was more effective against ethanol-induced gastric ulcers. The extracts also significantly (P < .05) inhibited intestinal motility, with ME showing greater activity. Oral administration of AE and ME up to 5,000 mg/kg did not produce lethality or signs of acute toxicity in mice after 24 hours. The extracts of unripe C. papaya contain terpenoids, alkaloids, flavonoids, carbohydrates, glycosides, saponins, and steroids. The cytoprotective and antimotility properties of the extracts may account for the anti-ulcer property of the unripe fruit.
采用乙醇和吲哚美辛诱导的大鼠胃溃疡模型评价了番木瓜（Carica papaya）未成熟全果的水（AE）和甲醇（ME）提取物的抗溃疡潜力。还研究了提取物对小肠推进的影响。与对照组相比，提取物在两种实验模型中均显著降低了溃疡指数（P<.05）。ME 对吲哚美辛诱导的溃疡显示出更好的保护作用，而 AE 对乙醇诱导的胃溃疡更有效。提取物还显著（P<.05）抑制了肠道蠕动，ME 表现出更大的活性。AE 和 ME 的口服剂量高达 5000mg/kg，在 24 小时后，小鼠未出现致死或急性毒性的迹象。番木瓜未成熟果实的提取物含有萜类、生物碱、类黄酮、碳水化合物、糖苷、皂苷和类固醇。提取物的细胞保护和抗运动性质可能是未成熟果实具有抗溃疡特性的原因。
