Singapore Eye Research Institute, Singapore, Republic of Singapore.
Ophthalmology. 2010 May;117(5):993-997.e4. doi: 10.1016/j.ophtha.2009.10.003. Epub 2010 Jan 15.
To evaluate the possible associations between dietary factors and myopia.
Cross-sectional study.
Eight hundred fifty-one Chinese schoolchildren from the Singapore Cohort Study of Risk Factors for Myopia.
Diet was assessed using a semiquantitative food-frequency questionnaire. Spherical equivalent (SE) refraction was assessed with an autorefractometer, and axial length (AL) by contact ultrasound A-scan biometry.
Myopia was defined as SE< or =-0.5 diopters (D). Spherical equivalent and AL were analyzed by quartile groups.
The mean age (+/-standard deviation) was 12.81+/-0.83 years, approximately half were male (422 children [49.6%]), and 653 (73.8%) children had myopia. In multivariate models, AL was longest in the highest quartile group of total cholesterol intake compared with the lowest (adjusted mean [95% confidence interval], 24.66 [24.62-24.71] mm vs. 24.32 [24.27-24.36] mm; P = 0.026, for trend) and was longest in the highest quartile group of saturated fat intake compared with the lowest (24.65 [24.60-24.70] vs. 24.36 [24.32-24.41] mm; P = 0.039, for trend). None of the nutrients was associated with SE or a diagnosis of myopia.
Higher saturated fat and cholesterol intake are associated with longer AL in otherwise healthy Singapore Chinese schoolchildren.
评估饮食因素与近视之间可能存在的关联。
横断面研究。
来自新加坡近视危险因素研究的 851 名中国学童。
使用半定量食物频率问卷评估饮食。使用自动折射仪评估等效球镜（SE）屈光度，使用接触式超声 A 扫描生物测量仪评估眼轴（AL）长度。
近视定义为 SE<或=-0.5 屈光度（D）。按四分位组分析 SE 和 AL。
平均年龄（+/-标准差）为 12.81+/-0.83 岁，约有一半为男性（422 名儿童[49.6%]），653 名（73.8%）儿童患有近视。在多变量模型中，总胆固醇摄入量最高四分位组的 AL 比最低四分位组长（调整后的平均值[95%置信区间]，24.66 [24.62-24.71]mm 与 24.32 [24.27-24.36]mm；P=0.026，趋势），饱和脂肪摄入量最高四分位组的 AL 比最低四分位组长（24.65 [24.60-24.70]mm 与 24.36 [24.32-24.41]mm；P=0.039，趋势）。没有任何营养素与 SE 或近视诊断相关。
在其他方面健康的新加坡华裔学童中，较高的饱和脂肪和胆固醇摄入量与较长的 AL 相关。
