饮食因素、近视与儿童眼球轴长

Dietary factors, myopia, and axial dimensions in children.

机构信息

Singapore Eye Research Institute, Singapore, Republic of Singapore.

出版信息

Ophthalmology. 2010 May;117(5):993-997.e4. doi: 10.1016/j.ophtha.2009.10.003. Epub 2010 Jan 15.

DOI:10.1016/j.ophtha.2009.10.003

PMID:20079928

Abstract

PURPOSE

To evaluate the possible associations between dietary factors and myopia.

DESIGN

Cross-sectional study.

PARTICIPANTS

Eight hundred fifty-one Chinese schoolchildren from the Singapore Cohort Study of Risk Factors for Myopia.

METHODS

Diet was assessed using a semiquantitative food-frequency questionnaire. Spherical equivalent (SE) refraction was assessed with an autorefractometer, and axial length (AL) by contact ultrasound A-scan biometry.

MAIN OUTCOME MEASURES

Myopia was defined as SE< or =-0.5 diopters (D). Spherical equivalent and AL were analyzed by quartile groups.

RESULTS

The mean age (+/-standard deviation) was 12.81+/-0.83 years, approximately half were male (422 children [49.6%]), and 653 (73.8%) children had myopia. In multivariate models, AL was longest in the highest quartile group of total cholesterol intake compared with the lowest (adjusted mean [95% confidence interval], 24.66 [24.62-24.71] mm vs. 24.32 [24.27-24.36] mm; P = 0.026, for trend) and was longest in the highest quartile group of saturated fat intake compared with the lowest (24.65 [24.60-24.70] vs. 24.36 [24.32-24.41] mm; P = 0.039, for trend). None of the nutrients was associated with SE or a diagnosis of myopia.

CONCLUSIONS

Higher saturated fat and cholesterol intake are associated with longer AL in otherwise healthy Singapore Chinese schoolchildren.

摘要

目的

评估饮食因素与近视之间可能存在的关联。

设计

横断面研究。

参与者

来自新加坡近视危险因素研究的 851 名中国学童。

方法

使用半定量食物频率问卷评估饮食。使用自动折射仪评估等效球镜（SE）屈光度，使用接触式超声 A 扫描生物测量仪评估眼轴（AL）长度。

主要观察指标

近视定义为 SE<或=-0.5 屈光度（D）。按四分位组分析 SE 和 AL。

结果

平均年龄（+/-标准差）为 12.81+/-0.83 岁，约有一半为男性（422 名儿童[49.6%]），653 名（73.8%）儿童患有近视。在多变量模型中，总胆固醇摄入量最高四分位组的 AL 比最低四分位组长（调整后的平均值[95%置信区间]，24.66 [24.62-24.71]mm 与 24.32 [24.27-24.36]mm；P=0.026，趋势），饱和脂肪摄入量最高四分位组的 AL 比最低四分位组长（24.65 [24.60-24.70]mm 与 24.36 [24.32-24.41]mm；P=0.039，趋势）。没有任何营养素与 SE 或近视诊断相关。