School of Biosciences, University of Exeter, Exeter EX4 4QD, United Kingdom.
Plant Physiol. 2010 Mar;152(3):1562-73. doi: 10.1104/pp.109.152173. Epub 2010 Jan 15.
Systemic acquired resistance is a widespread phenomenon in the plant kingdom that confers heightened and often enduring immunity to a range of diverse pathogens. Systemic immunity develops through activation of plant disease resistance protein signaling networks following local infection with an incompatible pathogen. The accumulation of the phytohormone salicylic acid in systemically responding tissues occurs within days after a local immunizing infection and is essential for systemic resistance. However, our knowledge of the signaling components underpinning signal perception and the establishment of systemic immunity are rudimentary. Previously, we showed that an early and transient increase in jasmonic acid in distal responding tissues was central to effective establishment of systemic immunity. Based upon predicted transcriptional networks induced in naive Arabidopsis (Arabidopsis thaliana) leaves following avirulent Pseudomonas syringae challenge, we show that a variety of auxin mutants compromise the establishment of systemic immunity. Linking together transcriptional and targeted metabolite studies, our data provide compelling evidence for a role of indole-derived compounds, but not auxin itself, in the establishment and maintenance of systemic immunity.
系统获得性抗性是植物界中广泛存在的现象，它赋予植物对多种不同病原体的高度和持久的免疫力。系统免疫通过植物疾病抗性蛋白信号网络的激活而发展，这种激活是在与不相容病原体局部感染后发生的。在局部免疫感染后数天内，植物激素水杨酸在系统反应组织中的积累对于系统抗性是必需的。然而，我们对于信号感知和系统免疫建立的信号转导成分的了解还很基础。以前，我们表明，在远端反应组织中茉莉酸的早期和短暂增加是有效建立系统免疫的关键。基于拟南芥（Arabidopsis thaliana）叶片在无毒假单胞菌挑战后的预测转录网络，我们表明各种生长素突变体破坏了系统免疫的建立。将转录组学和靶向代谢组学研究联系起来，我们的数据为吲哚衍生化合物（而不是生长素本身）在系统免疫的建立和维持中的作用提供了有力的证据。
