儿童和成人胃肠道通透性检测中时间、性别和年龄的影响。
Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults.
机构信息
Phoenix Children's Hospital, Phoenix, Arizona, USA.
出版信息
J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):269-75. doi: 10.1097/MPG.0b013e3181aa3aa9.
OBJECTIVES
Measurement of gastrointestinal (GI) permeability is commonly used in research and often used clinically. Despite its utility, little is known about sugar excretion timeframes or the potential effects of age and sex on GI permeability testing. We seek to determine the timeframes of sugar excretion and the potential effects of age and sex on urinary recovery of the sugars.
SUBJECTS AND METHODS
Healthy adults (n = 17) and children (n = 15) fasted 4 hours after the evening meal and then ingested a solution of sucrose, lactulose, mannitol, and sucralose. Urine was collected at 30, 60, and 90 minutes after ingestion and then each time the subjects voided during the next 24 hours. Each urine void was collected separately.
RESULTS
Median age for the adults was 47.5 years (range 21-57 years) and for children 10 years (range 5-17 years). There were no differences between children and adults in mean percent dose of sugar recovered. The time of peak urinary recovery of the sugars was generally similar between children and adults. Sucrose urinary recovery declined with age (P = 0.008; r2 = 0.19) unrelated to sex. Lactulose and sucralose urinary recovery declined with age in females (P = 0.05, r2 = 0.24 and P = 0.011, r2 = 0.41; respectively) but not in males.
CONCLUSIONS
Overall, sugar urinary recovery is comparable in children and adults. Specific sugar urinary recovery may change as a function of age and/or sex. These results need to be taken into account when planning and interpreting gastrointestinal permeability studies.
目的
胃肠道（GI）通透性的测量通常用于研究，并且经常在临床上使用。尽管其具有实用性，但对于糖排泄的时间框架或年龄和性别对 GI 通透性测试的潜在影响知之甚少。我们旨在确定糖排泄的时间框架以及年龄和性别对尿糖回收的潜在影响。
受试者和方法
健康成年人（n=17）和儿童（n=15）在晚餐后禁食 4 小时，然后摄入蔗糖、乳果糖、甘露醇和三氯蔗糖溶液。摄入后 30、60 和 90 分钟收集尿液，然后在接下来的 24 小时内每次受试者排尿时收集尿液。每次排尿都单独收集。
结果
成年人的中位年龄为 47.5 岁（范围 21-57 岁），儿童为 10 岁（范围 5-17 岁）。儿童和成年人之间回收的糖剂量的平均百分比没有差异。糖的尿液峰值回收时间在儿童和成年人之间通常相似。蔗糖的尿液回收随年龄下降（P=0.008；r2=0.19），与性别无关。乳果糖和三氯蔗糖的尿液回收随女性年龄下降（P=0.05，r2=0.24 和 P=0.011，r2=0.41；分别），但在男性中则不然。
结论
总体而言，儿童和成年人的糖尿回收情况相当。特定糖的尿回收可能会随着年龄和/或性别而变化。在计划和解释胃肠道通透性研究时，需要考虑这些结果。
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