Dimkov A, Nicholson J W, Gjorgievska E
Clinic for Pediatric and Preventive Dentistry, Faculty of Dentistry, Skopje, R. Macedonia.
Prilozi. 2009 Dec;30(2):219-37.
Apart from their release of fluorine ions, GICs can potentially be used as templates for the release of other active antimicrobial ingredients. The aim of this study was to investigate the possibility of incorporating an antimicrobial compound into a glass-ionomer cement. For the realization of the aim set we used the commercially available ChemFlex glass-ionomer cement, a material widely used in restorative dentistry. Three groups of the commercial ChemFlex glass-ionomer were prepared, with no antimicrobial compound added, of 5 samples each - to serve as a control group; and another three groups of the same cement of 5 specimens each were also prepared, but each with a different concentration of benzalkonium chloride added to it - 1%, 2% and 3%, respectively - a total of 15 samples. The concentrations of released ions - fluoride and chloride - were measured at predetermined time instants. In order to determine the amount of ions (Cl(-) and F(-)) released into the medium (deionized water) in which the samples had been placed, we conducted measurements with ion-selective electrodes for chloride and fluoride at different time instants. We carried out an analysis of the release of chloride in order to see whether and in what concentrations such release of chlorine, a constituent of benzalkonium chloride, occurs, and thus to conclude about the possibility of the antimicrobial effect of the glass-ionomer cement. The common feature of all three percentages of benzalkonium chloride was that there were differences between the concentrations of chloride released by the samples with and without the antimicrobial compound added.
除了释放氟离子外，玻璃离子水门汀还可能用作释放其他活性抗菌成分的模板。本研究的目的是探究将抗菌化合物掺入玻璃离子水门汀中的可能性。为实现设定的目标，我们使用了市售的ChemFlex玻璃离子水门汀，这是一种在修复牙科中广泛使用的材料。制备了三组市售的ChemFlex玻璃离子水门汀，每组5个样品，不添加抗菌化合物，作为对照组；还制备了另外三组相同的水门汀，每组5个样品，但分别添加了不同浓度的苯扎氯铵——1%、2%和3%，共15个样品。在预定的时间点测量释放离子——氟离子和氯离子——的浓度。为了确定样品所在介质（去离子水）中释放的离子（Cl⁻ 和F⁻）的量，我们在不同时间点用氯离子和氟离子选择性电极进行测量。我们对氯离子的释放进行了分析，以查看作为苯扎氯铵成分的氯是否以及以何种浓度释放，从而推断玻璃离子水门汀产生抗菌作用的可能性。添加苯扎氯铵的所有三个百分比的共同特征是，添加和未添加抗菌化合物的样品释放的氯离子浓度存在差异。
