Faculty of Dental Medicine, "Saints Cyril and Methodius" University of Skopje, Skopje, Macedonia.
Bluefield Centre for Biomaterials, London, UK.
Biomed Res Int. 2017;2017:2129807. doi: 10.1155/2017/2129807. Epub 2017 May 23.
Root canal sealers with antimicrobial activity are highly beneficial; therefore, their antimicrobial properties could be improved by incorporation of antimicrobial agents. In the present study, the release of the quaternary ammonium compounds from endodontic sealers admixed with either benzalkonium chloride (BC) or cetylpyridinium chloride (CPC) at loadings of 2% wt was monitored. The effect of these additives on the compressive strengths and their release from the sealers was determined after 1 and 4 weeks. All of the materials studied were found to be capable of releasing antimicrobial additive in useful quantities. The release of CPC occurred to a statistically significant greater extent than BC for all materials. The addition of both BC and CPC generally decreased the compressive strength of all the endodontic sealers, with the exception of CPC in AH Plus, where the compressive strength was significantly increased. This suggests that, for these endodontic sealers, the antimicrobial additives alter the setting chemistry. AH Plus is an epoxy-based material cured with an amine, and in this case the increase in compressive strength with CPC is attributed to an enhanced cure reaction with this system. In all other cases, the additive inhibited the cure reaction to a greater or lesser extent.
具有抗菌活性的根管封闭剂非常有益；因此，通过加入抗菌剂可以提高其抗菌性能。在本研究中，监测了在 2%wt 负载下与苄索氯铵（BC）或十六烷基吡啶氯（CPC）混合的根管封闭剂中季铵化合物的释放。测定了这些添加剂对密封剂抗压强度及其释放的影响，研究了在第 1 周和第 4 周。研究发现所有材料都能够以有用的量释放抗菌添加剂。对于所有材料，CPC 的释放量均明显大于 BC。BC 和 CPC 的添加通常会降低所有根管封闭剂的抗压强度，但 CPC 在 AH Plus 中的情况除外，其中 CPC 的抗压强度显著增加。这表明，对于这些根管封闭剂，抗菌添加剂改变了凝固化学。AH Plus 是一种用胺固化的环氧树脂基材料，在这种情况下，CPC 抗压强度的增加归因于与该体系的固化反应增强。在所有其他情况下，添加剂或多或少地抑制了固化反应。
