在一些宠物用减毒活疫苗中分离出一种传染性内源性逆转录病毒。
Isolation of an infectious endogenous retrovirus in a proportion of live attenuated vaccines for pets.
机构信息
Laboratory of Signal Transduction, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan.
出版信息
J Virol. 2010 Apr;84(7):3690-4. doi: 10.1128/JVI.02715-09. Epub 2010 Jan 27.
Abstract
The genomes of all animal species are colonized by endogenous retroviruses (ERVs). Although most ERVs have accumulated defects that render them incapable of replication, fully infectious ERVs have been identified in various mammals. In this study, we isolated a feline infectious ERV (RD-114) in a proportion of live attenuated vaccines for pets. Isolation of RD-114 was made in two independent laboratories using different detection strategies and using vaccines for both cats and dogs commercially available in Japan or the United Kingdom. This study shows that the methods currently employed to screen veterinary vaccines for retroviruses should be reevaluated.
摘要
所有动物物种的基因组都被内源性逆转录病毒（ERVs）所定植。尽管大多数 ERV 积累了缺陷，使其无法复制，但在各种哺乳动物中已经鉴定出了具有完全感染性的 ERV。在这项研究中，我们从宠物用的减毒活疫苗中分离出了一种猫传染性内源性逆转录病毒（RD-114）。RD-114 的分离是在两个独立的实验室中使用不同的检测策略完成的，使用的疫苗是在日本或英国商业化的猫和狗用疫苗。本研究表明，目前用于筛选兽医逆转录病毒疫苗的方法应该重新评估。
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