Department of Pediatrics, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Gastroenterol Res Pract. 2009;2009:701019. doi: 10.1155/2009/701019. Epub 2010 Jan 6.
Cyclic vomiting syndrome (CVS) shares many features with migraine headache, including auras, photophobia, and antimigrainous treatment response being traditionally viewed as a migraine variant. Aims. To determine whether CVS is associated with the same disorders as migraine headache, and compare these associations to those in healthy control subjects.
Cross-sectional study of patients utilizing the ODYSA instrument, evaluating the probability of 12 functional/autonomic diagnoses, CVS, migraine, orthostatic intolerance (OI), reflex syncope, interstitial cystitis, Raynaud's syndrome, complex regional pain syndrome (CRPS), irritable bowel syndrome, functional dyspepsia, functional abdominal pain, fibromyalgia, and chronic fatigue syndrome. Control subjects were age-matched gender-matched friends. Patients had to fulfill criteria for CVS or migraine, while control subjects could not.
103 subjects were studied, 21 with CVS, 46 with migraine and 36 healthy controls. CVS and migraine did not differ in the relative frequencies of fibromyalgia, OI, syncope, and functional dyspepsia. However, CVS patients did demonstrate a significantly elevated frequency of CRPS.
Although CVS and migraine clearly share many of the same comorbidities, they do differ in one important association, suggesting that they may not be identical in pathophysiology. Since OI is common in CVS, treatment strategies could also target this abnormality.
周期性呕吐综合征 (CVS) 与偏头痛有许多共同特征，包括先兆、畏光和抗偏头痛治疗反应，传统上被视为偏头痛的一种变体。目的。确定 CVS 是否与偏头痛相同的疾病有关，并将这些关联与健康对照组进行比较。
利用 ODYSA 仪器对患者进行横断面研究，评估 12 种功能/自主诊断、CVS、偏头痛、直立不耐受 (OI)、反射性晕厥、间质性膀胱炎、雷诺综合征、复杂性区域疼痛综合征 (CRPS) 、肠易激综合征、功能性消化不良、功能性腹痛、纤维肌痛和慢性疲劳综合征的可能性。对照组为年龄匹配的性别匹配的朋友。患者必须符合 CVS 或偏头痛的标准，而对照组则不能。
共研究了 103 名受试者，其中 21 名患有 CVS，46 名患有偏头痛，36 名健康对照组。CVS 和偏头痛在纤维肌痛、OI、晕厥和功能性消化不良的相对频率上没有差异。然而，CVS 患者确实表现出 CRPS 的频率明显升高。
尽管 CVS 和偏头痛显然有许多共同的合并症，但它们在一个重要的关联上存在差异，这表明它们在病理生理学上可能并不相同。由于 CVS 中 OI 很常见，因此治疗策略也可以针对这种异常。
