来自海南软珊瑚 Sinularia depressa 的罕见卡烷二萜。

Rare casbane diterpenoids from the Hainan soft coral Sinularia depressa.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2010 Feb 26;73(2):133-8. doi: 10.1021/np900484k.

DOI:10.1021/np900484k

PMID:20121250

Abstract

A series of nine casbane diterpenes, compounds 5-13, exhibiting either cis or trans ring junctions were isolated from the Hainan soft coral Sinularia depressa. The structures of this group of compounds, the basic member of which was named depressin (5), were established by detailed spectroscopic analysis. In addition, the absolute configuration of the main metabolite, 10-hydroxydepressin (7), and of its epimer, 1-epi-10-hydroxydepressin (8), was determined by a combination of conformational analysis and the modified Mosher's method. A stereochemical relationship between all isolated molecules was investigated by analyzing their circular dichroism profiles. Antiproliferative and antibacterial activities of the depressins were also evaluated.

摘要

从海南软珊瑚 Sinularia depressa 中分离得到了一系列具有顺式或反式环连接的 9 个 casbane 二萜类化合物 5-13。通过详细的光谱分析确定了该组化合物的结构，其中基本成员被命名为 depressin（5）。此外，通过构象分析和改进的 Mosher 方法相结合，确定了主要代谢产物 10-羟基 depressin（7）及其表异构体 1-epi-10-羟基 depressin（8）的绝对构型。通过分析它们的圆二色谱谱来研究所有分离分子之间的立体化学关系。还评估了 depressin 的抗增殖和抗菌活性。