Molecular Imaging Program at Stanford, the Bio-X Program and the Department of Radiology,Stanford University, Palo Alto, California 94305, USA.
Opt Lett. 2010 Feb 1;35(3):270-2. doi: 10.1364/OL.35.000270.
We developed a photoacoustic ocular imaging device and demonstrated its utility in imaging the deeper layers of the eye including the retina, choroid, and optic nerve. Using safe laser intensity, the photoacoustic system was able to visualize the blood distribution of an enucleated pig's eye and an eye of a living rabbit. Ultrasound images, which were simultaneously acquired, were overlaid on the photoacoustic images to visualize the eye's anatomy. Such a system may be used in the future for early detection and improved management of neovascular ocular diseases, including wet age-related macular degeneration and proliferative diabetic retinopathy.
我们开发了一种光声眼部成像设备，并展示了其在成像眼睛的深层组织（包括视网膜、脉络膜和视神经）方面的应用。该光声系统在使用安全激光强度的情况下，能够可视化一只去眼球猪眼和一只活兔眼的血液分布。同时获取的超声图像被叠加在光声图像上，以可视化眼睛的解剖结构。未来，这种系统可能用于早期检测和改善新生血管性眼病（包括湿性年龄相关性黄斑变性和增生性糖尿病视网膜病变）的管理。
