School of Dentistry, National Yang-Ming University, Taipei, Taiwan.
Oral Oncol. 2010 Mar;46(3):204-8. doi: 10.1016/j.oraloncology.2009.12.005. Epub 2010 Feb 6.
MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking miR-24 and using exogenous miR-24 expression indicated that miR-24 contributes to the growth of OSCC cells and that miR-24 may target p57. This study suggests that miR-24 is involved in the regulation of OSCC growth and that the miR-24's level in plasma may be validatable as a tumor marker for OSCC patients.
微小 RNA（miRNAs）在肿瘤发生过程中发挥重要作用。miR-24 定位于染色体 9q22 和 19p13，这是口腔鳞状细胞癌（OSCC）中经常发生改变的区域。本研究表明，miR-24 在 OSCC 组织中相对于对照样本上调。此外，OSCC 患者的血浆 miR-24 水平明显高于对照个体。miR-24 在 OSCC 细胞系中的表达也高于正常口腔角质形成细胞。阻断 miR-24 的实验和使用外源性 miR-24 表达表明，miR-24 有助于 OSCC 细胞的生长，并且 miR-24 可能靶向 p57。本研究表明，miR-24 参与 OSCC 生长的调节，并且血浆中 miR-24 的水平可能可作为 OSCC 患者的肿瘤标志物进行验证。
