Department of Respiratory Medicine, University of Medical Sciences, Poznan, Poland.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):49-52. doi: 10.1186/2047-783x-14-s4-49.
The relationship between obstructive sleep apnea (OSA) and cardiovascular disease is intensively discussed. Endothelial leukocyte adhesion molecule (E-selectin) is one of factors facilitating leukocyte migration to the subendothelial layer which could be considered proatherogenic. The aim of the study was to determine E-selectin levels and total plasma antioxidant status (TAS) in the blood of different stage OSA patients.
Non-smoking, OSA-suspected males, aged 30-63, were selected for the study. An EMBLA polysomnographic system was used to establish the severity of apneic episodes. The results of apnea/hypopnea index (AHI) allowed dividing patients into the following groups: OSA-0 with AHI 0-4.9 (n=14), OSA-1 with AHI 5-15 (n=14), OSA-2 with AHI 16-30 (n=13), OSA-3 with AHI > or =30 (n=13). Complete blood count (CBC), glycemia during oral glucose tolerance test, fasting plasma lipid profile, uric acid, and high sensitivity C-reactive protein (hsCRP) were estimated among routine parameters. We determined plasma concentrations of E-selectin and total antioxidant status.
We found progressively decreasing concentrations of TAS (P=0.03) and increased concentrations of E-selectin (P=0.0001) from OSA-0 to OSA-3 subjects. No correlation between E-selectin and metabolic parameters was noted. -
In the studied OSA groups, E-selectin appeared an independent proatherogenic factor.
阻塞性睡眠呼吸暂停（OSA）与心血管疾病的关系正在被深入讨论。内皮白细胞黏附分子（E-选择素）是促进白细胞向血管内皮下迁移的因素之一，被认为具有动脉粥样硬化形成作用。本研究旨在确定不同阶段 OSA 患者血液中 E-选择素水平和总血浆抗氧化状态（TAS）。
选择年龄 30-63 岁、不吸烟、疑有 OSA 的男性进行研究。使用 EMBLA 多导睡眠图系统确定呼吸暂停事件的严重程度。呼吸暂停/低通气指数（AHI）的结果允许将患者分为以下几组：AHI 为 0-4.9 的 OSA-0 组（n=14）、AHI 为 5-15 的 OSA-1 组（n=14）、AHI 为 16-30 的 OSA-2 组（n=13）、AHI 大于等于 30 的 OSA-3 组（n=13）。常规参数中包括全血细胞计数（CBC）、口服葡萄糖耐量试验期间的血糖、空腹血浆脂质谱、尿酸和高敏 C 反应蛋白（hsCRP）。我们测定了血浆 E-选择素和总抗氧化状态的浓度。
我们发现，从 OSA-0 到 OSA-3 患者，TAS 的浓度逐渐降低（P=0.03），E-选择素的浓度逐渐升高（P=0.0001）。E-选择素与代谢参数之间没有相关性。
在研究的 OSA 组中，E-选择素是一个独立的促动脉粥样硬化形成的因素。
