基于主体的宿主-病原体系统建模：成功与挑战
Agent-based modeling of host-pathogen systems: The successes and challenges.
作者信息
Bauer Amy L, Beauchemin Catherine A A, Perelson Alan S
机构信息
Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.
出版信息
Inf Sci (N Y). 2009 Apr 29;179(10):1379-1389. doi: 10.1016/j.ins.2008.11.012.
Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based models relevant to host-pathogen systems and discuss their contributions to our understanding of biological processes. We then point out some limitations and challenges of agent-based models and encourage efforts towards reproducibility and model validation.
基于主体的模型已被用于描述免疫学中的众多过程。基于这类模型的模拟已被用于增进我们对免疫学和疾病病理学的理解。我们综述了与宿主-病原体系统相关的各种基于主体的模型，并讨论了它们对我们理解生物过程的贡献。然后，我们指出了基于主体的模型的一些局限性和挑战，并鼓励为实现可重复性和模型验证而努力。
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