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本文引用的文献

1
Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food.不可消化的寡糖和多糖（膳食纤维）：它们的生理学以及在人类健康和食品中的作用
Compr Rev Food Sci Food Saf. 2002 Oct;1(3):90-109. doi: 10.1111/j.1541-4337.2002.tb00009.x.
2
Bovine milk glycome.牛乳糖组
J Dairy Sci. 2008 Oct;91(10):3768-78. doi: 10.3168/jds.2008-1305.
3
Oligosaccharides from milk.来自牛奶的寡糖。
J Nutr. 2007 Mar;137(3 Suppl 2):847S-9S. doi: 10.1093/jn/137.3.847S.
4
Process development for the production of prebiotic galacto-oligosaccharides from lactose using beta-galactosidase from Lactobacillus sp.利用来自乳酸杆菌属的β-半乳糖苷酶从乳糖生产益生元低聚半乳糖的工艺开发
Biotechnol J. 2007 Apr;2(4):480-5. doi: 10.1002/biot.200600230.
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Prebiotics in human milk: a review.母乳中的益生元：综述
Dig Liver Dis. 2006 Dec;38 Suppl 2:S291-4. doi: 10.1016/S1590-8658(07)60013-9.
6
A strategy for annotating the human milk glycome.一种注释人乳糖组的策略。
J Agric Food Chem. 2006 Oct 4;54(20):7471-80. doi: 10.1021/jf0615810.
7
Distribution of sialic acids in the milk of spanish mothers of full term infants during lactation.西班牙足月产婴儿母亲哺乳期乳汁中唾液酸的分布情况
J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):499-503. doi: 10.1097/00005176-200411000-00010.
8
Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides.傅里叶变换离子回旋共振质谱在寡糖中的应用。
Mass Spectrom Rev. 2005 Mar-Apr;24(2):232-64. doi: 10.1002/mas.20010.
9
Activation of large ions in FT-ICR mass spectrometry.傅里叶变换离子回旋共振质谱中大分子离子的激活
Mass Spectrom Rev. 2005 Mar-Apr;24(2):135-67. doi: 10.1002/mas.20012.
10
The first prebiotics in humans: human milk oligosaccharides.人类的首批益生元：母乳中的低聚糖。
J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S80-3. doi: 10.1097/01.mcg.0000128926.14285.25.

奶酪乳清超滤渗透物是乳寡糖的一个来源。

Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides.

作者信息

Barile Daniela, Tao Nannan, Lebrilla Carlito B, Coisson Jean-Daniel, Arlorio Marco, German J Bruce

机构信息

Department of Food Science and Technology, University of California, Davis, CA 95616, USA.

出版信息

Int Dairy J. 2009 Sep 1;19(9):524-530. doi: 10.1016/j.idairyj.2009.03.008.

DOI:10.1016/j.idairyj.2009.03.008
PMID:20161544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2805004/
Abstract

Previously undescribed oligosaccharides in bovine cheese whey permeate were characterized by a combination of nanoelectrospray Fourier Transform Ion Cyclotron Resonance (nESI-FTICR) mass spectrometry and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance (MALDI-FTICR) mass spectrometry. Oligosaccharide composition was elucidated by collision-induced dissociation within the ICR cell. In addition to sialyllactose (the most abundant oligosaccharide in bovine colostrum), we identified 14 other oligosaccharides, half of which have the same composition of human milk oligosaccharides. These oligosaccharides could potentially be used as additives in infant formula and products for the pharmaceutical industry. Because whey permeate is a by-product from the production of whey protein concentrate (WPC) and is readily available, it is an attractive source of oligosaccharides for potential application in human nutrition.

摘要

通过纳米电喷雾傅里叶变换离子回旋共振（nESI-FTICR）质谱和基质辅助激光解吸/电离傅里叶变换离子回旋共振（MALDI-FTICR）质谱相结合的方法，对牛乳清渗透液中以前未描述的低聚糖进行了表征。通过在ICR细胞内的碰撞诱导解离来阐明低聚糖的组成。除了唾液乳糖（牛乳初乳中最丰富的低聚糖）外，我们还鉴定出了其他14种低聚糖，其中一半与人乳低聚糖的组成相同。这些低聚糖有可能用作婴儿配方奶粉和制药行业产品中的添加剂。由于乳清渗透液是生产乳清蛋白浓缩物（WPC）的副产品，且易于获得，因此它是一种有吸引力的低聚糖来源，有可能应用于人类营养领域。