Division of Substance Abuse, University Hospitals of Geneva, Rue Verte 2, CH-1205 Geneva, Switzerland.
Eat Weight Disord. 2009 Dec;14(4):e225-30. doi: 10.1007/BF03325121.
The present study explores sweet stimuli effects on hunger and negative alliesthesia in patients treated with antipsychotic drugs and controls. Those phenomena were examined in relation to previous weight gain, eating and weight-related cognitions and type of sweet stimuli: aspartame or sucrose. Alliesthesia is delayed in participants who gained weight regardless of cross group differences. A similar reduction of hunger was observed after the intake of two kinds of sweet stimuli (aspartame or sucrose) whereas alliesthesia measures were not affected. Whereas atypical antipsychotic drug-induced weight gain is linked to delayed satiety, the phenomenon is similar in magnitude in non-psychiatric controls who gained weight.
本研究探讨了甜味刺激对接受抗精神病药物治疗的患者和对照组的饥饿感和负性味觉的影响。这些现象与先前的体重增加、饮食和与体重相关的认知以及甜味刺激的类型(阿斯巴甜或蔗糖)有关。无论跨组差异如何,体重增加的参与者的味觉延迟。摄入两种甜味刺激物(阿斯巴甜或蔗糖)后,饥饿感均有相似程度的降低,而味觉延迟测量值不受影响。虽然非典型抗精神病药引起的体重增加与饱腹感延迟有关,但在体重增加的非精神科对照组中,这种现象的程度相似。