Samuel Lunenfeld Research Institute, Department of Molecular Genetics, University of Toronto, Toronto, Canada.
Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a003376. doi: 10.1101/cshperspect.a003376.
The fur on a cat's back, the scales on a fish, or the bristles on a fly are all beautifully organized, with a high degree of polarization in their surface organization. Great progress has been made in understanding how individual cell polarity is established, but our understanding of how cells coordinate their polarity in forming coherent tissues is still fragmentary. The organization of cells in the plane of the epithelium is known as planar cell polarity (PCP), and studies in the past decade have delineated a genetic pathway for the control of PCP. This review will first briefly review data from the Drosophila field, where PCP was first identified and genetically characterized, and then explore how vertebrate tissues become polarized during development.
猫的背部的毛、鱼的鳞片或苍蝇的刚毛都组织得非常完美，其表面组织具有高度的极化。尽管人们在理解单个细胞极性的建立方面已经取得了很大的进展，但对于细胞如何协调其极性以形成连贯的组织仍然知之甚少。上皮细胞平面的细胞组织称为平面细胞极性（PCP），过去十年的研究已经描绘出控制 PCP 的遗传途径。这篇综述首先将简要回顾最初在果蝇领域中发现并在遗传学上进行了特征描述的 PCP 的相关数据，然后探讨了在发育过程中，脊椎动物组织是如何变得极化的。
