光学微血管造影图像显示颅骨完整的小鼠的结构和功能脑血流灌注。
Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact.
机构信息
Department of Biomedical Engineering, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA.
出版信息
J Biophotonics. 2011 Jan;4(1-2):57-63. doi: 10.1002/jbio.201000001. Epub 2010 Feb 22.
Abstract
Alteration in regional cerebral blood flow (CBF) is the direct result of changes in neuronal activity. It is crucial to monitor the spatio-temporal characteristics of cerebro-vascular blood perfusion in the studies of cerebral diseases. Optical micro-angiography (OMAG) is a recently developed imaging technique capable of resolving 3D distribution of dynamic blood perfusion at a capillary level resolution within microcirculatory beds in vivo. The authors report the applications of OMAG in mouse ischemic stroke model. The study demonstrates that OMAG is a useful method capable of providing in vivo serial assessment of 3D cerebro-vascular pathophysiology with high sensitivity, and therefore, has the potential for use in the study of brain disorders and repairs.
摘要
区域性脑血流（CBF）的改变是神经元活动变化的直接结果。在研究脑部疾病时，监测脑血管灌注的时空特征至关重要。光学微血管造影（OMAG）是一种最近开发的成像技术，能够以毛细血管水平的分辨率解析活体微循环床内动态血流灌注的 3D 分布。作者报告了 OMAG 在小鼠缺血性中风模型中的应用。该研究表明，OMAG 是一种有用的方法，能够提供高灵敏度的体内 3D 脑血管病理生理学的连续评估，因此具有用于研究脑部疾病和修复的潜力。
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本文引用的文献
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