Dyogen Group, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Centre National de la Recherche Scientifique UMR8197, Institut National de la Santé et de la Recherche Médicale U1024, 75005 Paris, France.
Bioinformatics. 2010 Apr 15;26(8):1119-21. doi: 10.1093/bioinformatics/btq079. Epub 2010 Feb 24.
UNLABELLED: Comparative genomics remains a pivotal strategy to study the evolution of gene organization, and this primacy is reinforced by the growing number of full genome sequences available in public repositories. Despite this growth, bioinformatic tools available to visualize and compare genomes and to infer evolutionary events remain restricted to two or three genomes at a time, thus limiting the breadth and the nature of the question that can be investigated. Here we present Genomicus, a new synteny browser that can represent and compare unlimited numbers of genomes in a broad phylogenetic view. In addition, Genomicus includes reconstructed ancestral gene organization, thus greatly facilitating the interpretation of the data. AVAILABILITY: Genomicus is freely available for online use at http://www.dyogen.ens.fr/genomicus while data can be downloaded at ftp://ftp.biologie.ens.fr/pub/dyogen/genomicus.
未加标签:比较基因组学仍然是研究基因组织进化的关键策略,而且随着越来越多的完整基因组序列在公共存储库中可用,这种首要地位得到了加强。尽管有了这种增长,但可用于可视化和比较基因组以及推断进化事件的生物信息学工具仍然一次只能限制在两个或三个基因组,从而限制了可以研究的广度和问题的性质。在这里,我们介绍了 Genomicus,这是一种新的同线性浏览器,可以在广泛的系统发育视图中表示和比较无限数量的基因组。此外,Genomicus 包括重建的祖先基因组织,从而极大地促进了数据的解释。
可用性:Genomicus 可免费在线使用,网址为 http://www.dyogen.ens.fr/genomicus,而数据可从 ftp://ftp.biologie.ens.fr/pub/dyogen/genomicus 下载。
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