来自泽兰（水苏）的透明质酸酶抑制剂。

Hyaluronidase inhibitors from Takuran, Lycopus lucidus.

作者信息

Murata Toshihiro, Watahiki Mai, Tanaka Yu, Miyase Toshio, Yoshizaki Fumihiko

机构信息

Department of Pharmacognosy, Tohoku Pharmaceutical University, Sendai 981-8558,Japan.

出版信息

Chem Pharm Bull (Tokyo). 2010 Mar;58(3):394-7. doi: 10.1248/cpb.58.394.

DOI:10.1248/cpb.58.394

PMID:20190448

Abstract

Takuran is a traditional herbal medicine that is produced from the herbal plant Lycopus lucidas TURCZ. (Lamiaceae). Takuran is used as a treatment for diseases in women. From Takuran, four new phenylpropanoids along with 18 known compounds were isolated, and their structures were elucidated by spectroscopic analyses. Five phenylpropanoids isolated from the plant showed hyaluronidase inhibitory activity comparable to that of rosmarinic acid.

摘要

泽兰是一种传统草药，由唇形科植物光萼水苏（Lycopus lucidas TURCZ.）制成。泽兰用于治疗女性疾病。从泽兰中分离出四种新的苯丙素类化合物以及18种已知化合物，并通过光谱分析阐明了它们的结构。从该植物中分离出的五种苯丙素类化合物显示出与迷迭香酸相当的透明质酸酶抑制活性。