来自日本通泉草的透明质酸酶抑制剂。

Hyaluronidase inhibitors from Keiskea japonica.

作者信息

Murata Toshihiro, Miyase Toshio, Yoshizaki Fumihiko

机构信息

Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2012;60(1):121-8. doi: 10.1248/cpb.60.121.

DOI:10.1248/cpb.60.121

PMID:22223383

Abstract

An extract of Keiskea japonica MIQ. showed an inhibitory effect on hyaluronidase activity. From the extract, four new phenylpropanoids, two new maltol glycosides, two new monoterpene glycosides, and two new phenolic compounds were isolated together with 19 known compounds. Among these constituents, two phenylpropanoids and a flavone glucuronide were revealed as hyaluronidase inhibitors.

摘要

毛叶香茶菜提取物对透明质酸酶活性有抑制作用。从该提取物中分离得到4个新的苯丙素类化合物、2个新的麦芽酚糖苷、2个新的单萜糖苷和2个新的酚类化合物，以及19个已知化合物。在这些成分中，2个苯丙素类化合物和1个黄酮葡糖醛酸苷被发现是透明质酸酶抑制剂。