上位性相互作用。
Epistatic interactions.
作者信息
VanderWeele Tyler J
机构信息
Harvard University, USA.
出版信息
Stat Appl Genet Mol Biol. 2010;9(1):Article 1. doi: 10.2202/1544-6115.1517. Epub 2010 Jan 6.
Abstract
The term "epistasis" is sometimes used to describe some form of statistical interaction between genetic factors and is alternatively sometimes used to describe instances in which the effect of a particular genetic variant is masked by a variant at another locus. In general statistical tests for interaction are of limited use in detecting "epistasis" in the sense of masking. It is, however, shown that there are relations between empirical data patterns and epistasis that have not been previously noted. These relations can sometimes be exploited to empirically test for "epistatic interactions" in the sense of the masking of the effect of a particular genetic variant by a variant at another locus.
摘要
“上位性”一词有时用于描述遗传因素之间某种形式的统计相互作用，有时也用于描述特定基因变异的效应被另一位点的变异所掩盖的情况。一般来说，用于检测相互作用的统计检验在检测掩盖意义上的“上位性”方面用途有限。然而，研究表明，经验数据模式与上位性之间存在着以前未被注意到的关系。这些关系有时可用于从特定基因变异的效应被另一位点的变异所掩盖的意义上，对“上位性相互作用”进行实证检验。
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