果蝇中的基因转换以及减数分裂突变体mei-9和mei-218的影响。
Gene conversion in Drosophila and the effects of the meiotic mutants mei-9 and mei-218.
作者信息
Curtis D, Bender W
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Genetics. 1991 Apr;127(4):739-46. doi: 10.1093/genetics/127.4.739.
Abstract
Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were continuous, and displayed no obvious hot spots of initiation. Some unusual conversion events were found in the mei-218 and mei-9 samples, although most events were indistinguishable from wild-type tracts in their length and continuity.
摘要
将野生型雌性产生的简单减数分裂基因转换片段与来自两个减数分裂突变体mei-9和mei-218的片段进行比较。通过变性梯度凝胶和DNA测序确定转换片段的位置和长度。野生型中的转换片段平均长度为885个碱基对，是连续的，并且没有明显的起始热点。在mei-218和mei-9样本中发现了一些不寻常的转换事件，尽管大多数事件在长度和连续性上与野生型片段没有区别。
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本文引用的文献
1
Hybrid DNA tracts may start at different sites during meiotic recombination in gene b2 of Ascobolus.在 Ascobolus 基因 b2 的减数分裂重组过程中，杂种 DNA 片段可能从不同的位点开始。
EMBO J. 1988 Jan;7(1):253-9. doi: 10.1002/j.1460-2075.1988.tb02807.x.
2
Mismatch repair, gene conversion, and crossing-over in two recombination-defective mutants of Drosophila melanogaster.黑腹果蝇两个重组缺陷突变体中的错配修复、基因转换和交叉互换
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5961-5. doi: 10.1073/pnas.79.19.5961.
3
Further observations on intragenic recombination in Drosophila melanogaster.黑腹果蝇基因内重组的进一步观察
Genet Res. 1981 Dec;38(3):281-96. doi: 10.1017/s0016672300020619.
4
Chromosomal walking and jumping to isolate DNA from the Ace and rosy loci and the bithorax complex in Drosophila melanogaster.通过染色体步移和跳查从黑腹果蝇的Ace和玫瑰色基因座以及双胸复合体中分离DNA。
J Mol Biol. 1983 Jul 25;168(1):17-33. doi: 10.1016/s0022-2836(83)80320-9.
5
The double-strand-break repair model for recombination.用于重组的双链断裂修复模型。
Cell. 1983 May;33(1):25-35. doi: 10.1016/0092-8674(83)90331-8.
6
The synaptonemal complex in genetic segregation.遗传分离中的联会复合体。
Annu Rev Genet. 1984;18:331-413. doi: 10.1146/annurev.ge.18.120184.001555.
7
Studies on gene conversion and its relationship to linked exchange in Drosophila melanogaster.黑腹果蝇中基因转换及其与连锁交换关系的研究。
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8
On recombination-defective meiotic mutants in Drosophila melanogaster.关于黑腹果蝇中重组缺陷型减数分裂突变体
Genetics. 1974 Mar;76(3):453-75. doi: 10.1093/genetics/76.3.453.
9
A genetic and molecular analysis of DNA repair in Drosophila.
J Cell Sci Suppl. 1987;6:39-60. doi: 10.1242/jcs.1984.supplement_6.3.
10
Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster.果蝇中黄嘌呤脱氢酶结构基因（玫瑰色基因座）的序列。
Genetics. 1987 May;116(1):67-73. doi: 10.1093/genetics/116.1.67.
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