肠道病毒71型VP1区域的基因分析显示，2008年中国中部出现了A基因型。
Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008.
作者信息
Yu Haiyang, Chen Wei, Chang Hongwei, Tang Renshu, Zhao Jun, Gan Lin, Liu Boyu, Chen Jason, Wang Mingli
机构信息
Department of Microbiology, Anhui Medical University, 230032, Hefei, Anhui, China.
出版信息
Virus Genes. 2010 Aug;41(1):1-4. doi: 10.1007/s11262-010-0472-9. Epub 2010 Mar 20.
Enterovirus 71 (EV71) strains from children were characterized by full-length VP1 nucleotide sequencing. Out of 22 clinical specimens, five isolates identified as EV71 were recovered by virus isolation. The VP1 sequences of the five isolates had more than 97.4% sequence identity with prototype virus BrCr, clustering in the genotype A lineage. This represents the first record of genotype A EV71 in China since the BrCr prototype strain was discovered in the USA in 1969.
通过对儿童肠道病毒71型（EV71）毒株进行全长VP1核苷酸测序来进行特征分析。在22份临床标本中，通过病毒分离培养出5株鉴定为EV71的分离株。这5株分离株的VP1序列与原型病毒BrCr的序列同一性超过97.4%，聚类于A基因型谱系。这是自1969年在美国发现BrCr原型株以来，中国首次记录到A基因型EV71。
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