Yu Haiyang, Chen Wei, Chang Hongwei, Tang Renshu, Zhao Jun, Gan Lin, Liu Boyu, Chen Jason, Wang Mingli
Department of Microbiology, Anhui Medical University, 230032, Hefei, Anhui, China.
Virus Genes. 2010 Aug;41(1):1-4. doi: 10.1007/s11262-010-0472-9. Epub 2010 Mar 20.
Enterovirus 71 (EV71) strains from children were characterized by full-length VP1 nucleotide sequencing. Out of 22 clinical specimens, five isolates identified as EV71 were recovered by virus isolation. The VP1 sequences of the five isolates had more than 97.4% sequence identity with prototype virus BrCr, clustering in the genotype A lineage. This represents the first record of genotype A EV71 in China since the BrCr prototype strain was discovered in the USA in 1969.
通过对儿童肠道病毒71型（EV71）毒株进行全长VP1核苷酸测序来进行特征分析。在22份临床标本中，通过病毒分离培养出5株鉴定为EV71的分离株。这5株分离株的VP1序列与原型病毒BrCr的序列同一性超过97.4%，聚类于A基因型谱系。这是自1969年在美国发现BrCr原型株以来，中国首次记录到A基因型EV71。
