Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, USA.
J Am Chem Soc. 2010 Apr 14;132(14):5024-6. doi: 10.1021/ja100503b.
We report for the first time single-walled carbon nanotube (SWNT)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weakly charged or uncharged molecules using a displacement format. The detection of glucose, a small, weakly charged molecule, by displacement of plant lectin (concavalin A) bound to a polysaccharide (dextran) immobilized on SWNTs with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.
我们首次报道了基于单壁碳纳米管 (SWNT) 的化学电阻式亲和传感器，该传感器采用置换格式，可实现对小的、带弱电荷或不带电荷的分子进行高灵敏度和选择性的检测。我们以植物凝集素（伴刀豆球蛋白 A）与多糖（葡聚糖）结合并固定在 SWNT 上来检测葡萄糖（一种小的、带弱电荷的分子），证明了其具有皮摩尔级的灵敏度和选择性，可用于检测其他糖和人血清蛋白。
