Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
J Hosp Infect. 2010 Sep;76(1):23-5. doi: 10.1016/j.jhin.2010.01.017. Epub 2010 Mar 31.
Use of a fit-tested N95 or FFP2 mask is recommended to protect against transmission of airborne pathogens. This poses considerable logistic problems when preparing for, or dealing with, an epidemic. Some of these problems might be overcome by use of a compact reusable high-efficiency particulate air filtering mask that can be cut to size. We carried out a randomised controlled cross-over study to compare the efficacy of such a mask (Totobobo, Dream Lab One Pte Ltd, Singapore) with fit-tested N95 masks (1860 or 1860s or 1862; 3M, St Paul, MN, USA) in 22 healthy volunteers. The median (interquartile range) reduction in airborne particle counts was significantly higher [193-fold (145-200)] for N95 masks than for Totobobo masks [135-fold (83-184)] (P<0.05). There was no statistically significant difference between the proportion of subjects achieving a reduction of > or =100-fold between N95 (19/22) and Totobobo (16/22) masks. We conclude that use of the Totobobo mask without fit testing cannot be recommended, but its performance is sufficiently promising to warrant further investigation.
使用经过适合度测试的 N95 或 FFP2 口罩可以预防空气传播病原体的传播。在为应对传染病做准备或处理传染病时，这会带来相当大的后勤问题。通过使用可切割成合适尺寸的紧凑型可重复使用高效微粒空气过滤口罩，可以克服其中一些问题。我们进行了一项随机对照交叉研究，比较了这种口罩（新加坡 Dream Lab One Pte Ltd 的 Totobobo）与经过适合度测试的 N95 口罩（1860 或 1860s 或 1862；3M，明尼苏达州圣保罗）在 22 名健康志愿者中的功效。N95 口罩的空气中颗粒物计数降低中位数（四分位距）明显更高[193 倍（145-200）]，而 Totobobo 口罩则为[135 倍（83-184）]（P<0.05）。在 N95（19/22）和 Totobobo（16/22）口罩之间实现>或=100 倍减少的受试者比例之间没有统计学上的显著差异。我们得出的结论是，不进行适合度测试就使用 Totobobo 口罩不能被推荐，但它的性能非常有前途，值得进一步研究。
