Department of Health and Human Development, Montana State University, Box 173540, Bozeman, MT 59717, USA.
Eur J Appl Physiol. 2010 Aug;109(6):1067-76. doi: 10.1007/s00421-010-1448-0. Epub 2010 Apr 3.
Inflammation associated with adipose tissue is modulated by macronutrient availability. For example, glucose increases inflammation in obese but not lean individuals. Little is known about how macronutrient intake influences inflammation associated with muscle. The aim of this study was to determine the impact of macronutrient intake differences during recovery from eccentric exercise on the inflammatory response. The study was a cross-over design in which young men and women (n = 12) completed high and low carbohydrate (CHO) conditions. Both conditions consisted of six sets of ten maximal high-force eccentric contractions of the elbow flexors and extensors followed by a controlled diet for the first 8 h post-exercise. Glucose, insulin, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and C-reactive protein were measured from blood samples pre-exercise, 1.5, 4, 8, and 24 h post-exercise. Perceived muscle soreness, strength loss, and serum CK activity were measured through 120 h post-exercise. Perceived soreness was elevated (P < 0.001) at all time points post-exercise in both conditions and was higher (P < 0.05) in the high compared to the low CHO condition. IL-1beta increased (P = 0.05) 24 h post-exercise in the high compared to the low CHO condition. There was a trend (P = 0.06) for IL-6 to be elevated in the high compared to the low CHO condition. We conclude that inflammation induced by high-force eccentric exercise in skeletal muscle is greater when a high CHO compared to a low CHO diet is consumed during recovery.
与脂肪组织相关的炎症受宏量营养素供应的调节。例如，葡萄糖会增加肥胖者而不是瘦者的炎症。关于宏量营养素摄入如何影响与肌肉相关的炎症知之甚少。本研究旨在确定从离心运动恢复期间宏量营养素摄入差异对炎症反应的影响。该研究采用交叉设计，年轻男性和女性（n=12）完成高碳水化合物（CHO）和低碳水化合物（CHO）条件。两种条件均包括六组 10 次最大力的肘屈肌和伸肌离心收缩，随后在运动后 8 小时内进行控制饮食。在运动前、运动后 1.5、4、8 和 24 小时从血液样本中测量葡萄糖、胰岛素、肿瘤坏死因子-α、白细胞介素（IL）-1β、IL-6 和 C 反应蛋白。通过 120 小时的运动后测量肌肉酸痛、力量损失和血清 CK 活性。在两种条件下，运动后所有时间点的肌肉酸痛均升高（P < 0.001），且高 CHO 条件高于低 CHO 条件（P < 0.05）。与低 CHO 条件相比，高 CHO 条件在运动后 24 小时 IL-1β升高（P=0.05）。IL-6 升高的趋势（P=0.06），与低 CHO 条件相比，高 CHO 条件升高。我们的结论是，在从高力离心运动中恢复期间，与低 CHO 饮食相比，摄入高 CHO 饮食会导致骨骼肌炎症增加。
