Mai P L, Wideroff L, Greene M H, Graubard B I
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA.
Public Health Genomics. 2010;13(7-8):495-503. doi: 10.1159/000294469. Epub 2010 Apr 9.
A positive family history is a known risk factor for several cancers; thus, obtaining a thorough family cancer history is essential in cancer risk evaluation and prevention management.
The Family Health Study, a telephone survey in Connecticut, was conducted in 2001. A total of 1,019 participants with demographic information and family cancer history were included in this study. Prevalence of a positive family history of breast, colorectal, prostate, and lung cancer for first- and second-degree relatives was estimated. Logistic regression was used to compare prevalence by demographic factors.
A positive family history among first-degree relatives was reported by 10.9% (95% Confidence Interval, CI = 8.8-13.3) of respondents for breast cancer, 5.1% (95% CI = 3.9-6.7) for colorectal cancer, 7.0% (95% CI = 5.2-9.4) for prostate cancer, and 6.4% (95% CI = 4.9-8.3) for lung cancer. The reported prevalence of family history of specific cancers varied by sex, age and race/ethnicity of the respondents.
Family history prevalence for 4 of the most common adult solid tumors is substantial and the reported prevalence varied by respondent characteristics. Additional studies are needed to evaluate tools to promote accurate reporting of family history of cancer.
家族史是多种癌症已知的风险因素；因此，全面获取家族癌症病史对于癌症风险评估和预防管理至关重要。
2001年在康涅狄格州进行了一项名为家庭健康研究的电话调查。本研究共纳入了1019名有人口统计学信息和家族癌症病史的参与者。估计了一级和二级亲属中乳腺癌、结直肠癌、前列腺癌和肺癌家族史阳性的患病率。采用逻辑回归按人口统计学因素比较患病率。
10.9%（95%置信区间，CI = 8.8 - 13.3）的受访者报告一级亲属中有乳腺癌家族史阳性，5.1%（95%CI = 3.9 - 6.7）有结直肠癌家族史阳性，7.0%（95%CI = 5.2 - 9.4）有前列腺癌家族史阳性，6.4%（95%CI = 4.9 - 8.3）有肺癌家族史阳性。特定癌症家族史的报告患病率因受访者的性别、年龄和种族/族裔而异。
4种最常见的成人实体瘤的家族史患病率较高，且报告患病率因受访者特征而异。需要进一步研究以评估促进准确报告癌症家族史的工具。
