Miglietta A, Olivero A, Gadoni E, Gabriel L
Dipartimento di Medicina ed Oncologia Sperimentale, Sezione di Patologia Generale, Torino, Italy.
Chem Biol Interact. 1991;78(2):183-91. doi: 10.1016/0009-2797(91)90013-w.
4-Hydroxynonenal is one of the main breakdown products of lipid peroxidation. It has an antiproliferative effect, which may partly be the consequence of an interaction with cytoskeletal structures. Its effects on microtubular protein are compared with those of homologous aldehydes with the same number of carbon atoms, and with that of benzaldehyde. Unlike the other aliphatic aldehydes, this latter aldehyde does not impair microtubular functions at every concentration in the range. Nonanal has the greatest effect on tubulin polymerization, whereas it only slightly impairs colchicine binding activity. 2-Nonenal and 4-hydroxynonenal have less inhibiting effect on tubulin polymerization; their effect on colchicine binding activity is dose-dependent. The targets of 4-hydroxynonenal on tubulin are -SH groups; the action mechanism of other aldehydes has not yet been identified.
4-羟基壬烯醛是脂质过氧化的主要分解产物之一。它具有抗增殖作用，这可能部分是与细胞骨架结构相互作用的结果。将其对微管蛋白的作用与具有相同碳原子数的同源醛以及苯甲醛的作用进行了比较。与其他脂肪醛不同，后一种醛在该浓度范围内并非在每个浓度下都会损害微管功能。壬醛对微管蛋白聚合的影响最大，而它仅轻微损害秋水仙碱结合活性。2-壬烯醛和4-羟基壬烯醛对微管蛋白聚合的抑制作用较小；它们对秋水仙碱结合活性的影响呈剂量依赖性。4-羟基壬烯醛在微管蛋白上的作用靶点是-SH基团；其他醛的作用机制尚未确定。
