强直性脊柱炎中的细菌抗体。
Bacterial antibodies in ankylosing spondylitis.
作者信息
Mäki-Ikola O, Lehtinen K, Granfors K, Vainionpää R, Toivanen P
机构信息
Department of Medical Microbiology, Turku University, Finland.
出版信息
Clin Exp Immunol. 1991 Jun;84(3):472-5.
Abstract
Antibodies to Salmonellae, Yersiniae, Campylobacter jejuni, Borrelia burgdorferi, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis and Chlamydia trachomatis were measured by ELISA in the sera of 99 patients with ankylosing spondylitis. Increased prevalence of IgA and IgG class antibodies against K. pneumoniae and of IgA class against E. coli was observed in ankylosing spondylitis. No clear correlation between the disease activity and occurrence of antibodies was revealed. The results are in line with the previously published findings suggesting that K. pneumoniae may have a role in the aetiopathogenesis of ankylosing spondylitis.
摘要
采用酶联免疫吸附测定法（ELISA）检测了99例强直性脊柱炎患者血清中抗沙门氏菌、耶尔森氏菌、空肠弯曲菌、伯氏疏螺旋体、肺炎克雷伯菌、大肠杆菌、奇异变形杆菌和沙眼衣原体的抗体。强直性脊柱炎患者中，肺炎克雷伯菌IgA和IgG类抗体以及大肠杆菌IgA类抗体的患病率增加。未发现疾病活动与抗体出现之间存在明显相关性。这些结果与之前发表的研究结果一致，表明肺炎克雷伯菌可能在强直性脊柱炎的病因发病机制中起作用。
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