Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA.
Neuroimage. 2010 Oct 15;53(1):119-31. doi: 10.1016/j.neuroimage.2010.02.084. Epub 2010 May 5.
Neuroimaging studies are facilitated significantly when it is possible to recruit subjects and acquire data at multiple sites. However, the use of different scanners and acquisition protocols is a potential source of variability in multi-site data. In this work we present a multi-site study of the reliability of fMRI activation indices, where 10 healthy volunteers were scanned at 4 different sites while performing a working memory paradigm. Our results indicate that, even with different scanner manufacturers and field strengths, activation variability due to site differences is small compared to variability due to subject differences in this cognitive task, provided we choose an appropriate activation measure.
当能够在多个地点招募受试者和获取数据时,神经影像学研究将得到极大的促进。然而,使用不同的扫描仪和采集协议是多地点数据中变异性的一个潜在来源。在这项工作中,我们进行了一项 fMRI 激活指标的多中心研究,其中 10 名健康志愿者在执行工作记忆范式时在 4 个不同地点进行了扫描。我们的结果表明,即使使用不同的扫描仪制造商和磁场强度,如果我们选择适当的激活测量方法,与认知任务中由于个体差异引起的变异性相比,由于地点差异引起的激活变异性很小。