Fox Chase Cancer Center, Cheltenham, PA 19012, USA.
J Altern Complement Med. 2010 May;16(5):531-8. doi: 10.1089/acm.2009.0018.
Mindfulness-based stress reduction (MBSR) programs have consistently been shown to enhance the psychosocial well-being of participants. Given the well-established association between psychosocial factors and immunologic functioning, it has been hypothesized that enhanced psychosocial well-being among MBSR participants would be associated with corresponding changes in markers of immune activity.
The objectives of this study were to examine changes in psychosocial and immunologic measures in a heterogeneous patient sample following participation in a MBSR program.
A single-group, pretest/post-test design was utilized.
The intervention was conducted at an academic health center.
This pilot study involved 24 participants (aged 28-72 years). Inclusion criteria were as follows: > or =18 years of age, English-speaking, and no known autoimmune disorder.
The intervention was an 8-week MBSR program.
Distress and quality of life (QOL) measures included the Brief Symptom Inventory-18 and the Medical Outcomes Survey Short-Form Health Survey, respectively. Immunologic measures included natural killer (NK) cell cytolytic activity and C-reactive protein (CRP).
Patients completed psychosocial assessments and provided a blood sample at baseline (pre-MBSR) and within 2 weeks post-MBSR. Significant improvements in anxiety and overall distress as well as across multiple domains of QOL were observed from baseline to post-MBSR. Reductions in anxiety and overall distress were associated with reductions in CRP. Patients who reported improvement in overall mental well-being also showed increased NK cytolytic activity from pre- to post-MBSR, whereas patients who reported no improvement in mental well-being showed no change in NK cytolytic activity.
Positive improvement in psychologic well-being following MBSR was associated with increased NK cytolytic activity and decreased levels of CRP.
基于正念减压（MBSR）的项目已被证明可以增强参与者的心理社会幸福感。鉴于心理社会因素与免疫功能之间的既定关联，人们假设 MBSR 参与者的心理社会幸福感增强将与免疫活性标志物的相应变化相关。
本研究的目的是在参加 MBSR 项目后，检查异质患者样本中的心理社会和免疫测量值的变化。
采用单组、前后测试设计。
干预措施在学术医疗中心进行。
这项初步研究涉及 24 名参与者（年龄 28-72 岁）。纳入标准如下：> 18 岁，英语，无已知自身免疫性疾病。
干预措施是为期 8 周的 MBSR 项目。
患者在基线（MBSR 前）和 MBSR 后 2 周内完成了心理社会评估并提供了血液样本。从基线到 MBSR 后，焦虑和总体困扰以及多个生活质量（QOL）领域的评分均有显著改善。焦虑和总体困扰的减少与 CRP 的减少有关。报告整体心理健康状况改善的患者也表现出 MBSR 前后 NK 细胞细胞溶解活性的增加，而报告心理健康状况没有改善的患者则显示 NK 细胞细胞溶解活性没有变化。
MBSR 后心理幸福感的积极改善与 NK 细胞细胞溶解活性的增加和 CRP 水平的降低有关。
