Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Curr Opin Struct Biol. 2010 Jun;20(3):276-82. doi: 10.1016/j.sbi.2010.03.009. Epub 2010 Apr 22.
The past three decades have witnessed steady growth in our ability to harness DNA branched junctions as building blocks for programmable self-assembly of diverse supramolecular architectures. The DNA-origami method, which exploits the availability of long DNA sequences to template sophisticated nanostructures, has played a major role in extending this trend through the past few years. Today, two-dimensional and three-dimensional custom-shaped nanostructures comparable in mass to a small virus can be designed, assembled, and characterized with a prototyping cycle on the order of a couple of weeks.
在过去的三十年中，我们利用 DNA 分支结作为构建模块，实现各种超分子结构的可编程自组装的能力稳步增长。在过去的几年中，DNA 折纸方法通过利用长 DNA 序列来模板复杂的纳米结构，在扩展这一趋势方面发挥了重要作用。如今，可以设计、组装和表征与小型病毒质量相当的二维和三维定制形状的纳米结构，其原型制作周期约为几周。
