Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.
Bioinformatics. 2010 Jul 1;26(13):1662-3. doi: 10.1093/bioinformatics/btq247. Epub 2010 May 10.
Epigenetics, the study of heritable somatic phenotypic changes not related to DNA sequence, has emerged as a critical component of the landscape of gene regulation. The epigenetic layers, such as DNA methylation, histone modifications and nuclear architecture are now being extensively studied in many cell types and disease settings. Few software tools exist to summarize and interpret these datasets. We have created a toolbox of procedures to interrogate and visualize epigenomic data (both array- and sequencing-based) and make available a software package for the cross-platform R language.
The package is freely available under LGPL from the R-Forge web site (http://repitools.r-forge.r-project.org/)
表观遗传学是研究与 DNA 序列无关的可遗传体细胞表型变化的学科，现已成为基因调控领域的重要组成部分。现在，许多细胞类型和疾病环境中都在广泛研究表观遗传层，如 DNA 甲基化、组蛋白修饰和核结构。目前很少有软件工具可以总结和解释这些数据集。我们创建了一个程序工具箱来查询和可视化表观基因组数据（基于阵列和测序），并为跨平台 R 语言提供了一个软件包。
该软件包根据 LGPL 可从 R-Forge 网站（http://repitools.r-forge.r-project.org/）免费获得。
Zotero 插件