Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA.
J Cell Physiol. 2010 Sep;224(3):585-9. doi: 10.1002/jcp.22205.
Nucleotide excision repair (NER) is the primary DNA repair pathway that removes helix-distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and repair reactions have been identified and extensively characterized, and the NER pathway has been reconstituted in vitro, the regulatory pathways that govern the threshold levels of NER have not been fully elucidated. This mini-review focuses on recently discovered transcriptional and post-translational mechanisms that specify the capacity of NER, and suggests the potential implications of modulating NER activity in cancer prevention and therapeutic intervention.
核苷酸切除修复 (NER) 是一种主要的 DNA 修复途径，可去除由紫外线照射或化学致癌物引起的扭曲 DNA 链损伤，以确保基因组的完整性。尽管已经鉴定并广泛描述了执行损伤识别、切除和修复反应的核心 NER 蛋白，并且已经在体外重建了 NER 途径，但调节 NER 阈值水平的调控途径尚未完全阐明。本篇综述重点介绍了最近发现的转录和翻译后机制，这些机制特异性地规定了 NER 的能力，并提出了调节 NER 活性在癌症预防和治疗干预中的潜在意义。
