Oregon Health & Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA.
J Biomed Opt. 2010 Mar-Apr;15(2):020502. doi: 10.1117/1.3353958.
In this paper, we demonstrate that the optical microangiography (OAMG) is capable of depth-resolved imaging of directional blood perfusion within both retinal and choroid in the posterior segment of human eye. The study uses an OMAG system operating at 840 nm with an imaging speed at 27,000 A-scans per second. Sequentially registered multiple OMAG projection maps of small areas ( approximately 1 mm x 1 mm) are combined to provide directional blood flow images for a larger field of view. It takes approximately 3.7 sec to image a small area (1 x 1 mm(2)), and approximately 2.5 min for a larger field (3 x 3 mm(2)). Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology.
在本文中，我们证明了光学微血管造影术（OAMG）能够在人眼的后节中对视网膜和脉络膜内的定向血流灌注进行深度分辨成像。该研究使用了一个在 840nm 下工作、每秒 27000 次 A 扫描的 OMAG 系统。对小区域（约 1mm×1mm）的多个 OMAG 投影图进行顺序注册，以提供更大视野的定向血流图像。对一个小区域（1×1mm²）成像大约需要 3.7 秒，对一个更大的区域（3×3mm²）成像大约需要 2.5 分钟。最后，我们展示了 OMAG 在提供不同深度视网膜和脉络膜毛细血管水平微循环功能图像方面的卓越性能，这些图像与标准视网膜病理学具有很好的相关性。
