光学相干断层扫描血管造影中阈值处理的定义、基本原理及效果
The Definition, Rationale, and Effects of Thresholding in OCT Angiography.
作者信息
Cole Emily D, Moult Eric M, Dang Sabin, Choi WooJhon, Ploner Stefan B, Lee ByungKun, Louzada Ricardo, Novais Eduardo, Schottenhamml Julia, Husvogt Lennart, Maier Andreas, Fujimoto James G, Waheed Nadia K, Duker Jay S
机构信息
New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
出版信息
Ophthalmol Retina. 2017 Sep-Oct;1(5):435-447. doi: 10.1016/j.oret.2017.01.019. Epub 2017 Apr 5.
PURPOSE
To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA).
DESIGN
A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series.
PARTICIPANTS
Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed.
MAIN OUTCOME MEASURES
A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level.
RESULTS
Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal.
CONCLUSIONS
Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.
目的
探讨光学相干断层扫描血管造影（OCTA）中阈值设定的定义、基本原理及效果。
设计
结合回顾性病例系列中OCTA阈值设定效果的定性和定量分析，对OCTA阈值设定进行理论描述。
参与者
对4只眼睛进行了定性检查：1只来自27岁的对照者，1只来自78岁的渗出性年龄相关性黄斑变性（AMD）患者，1只来自58岁的近视患者，1只来自77岁的非渗出性AMD伴地图样萎缩（GA）患者。对1只来自75岁的非渗出性AMD伴GA患者的眼睛进行了定量分析。
主要观察指标
一个理论阈值设定模型以及对OCTA与阈值设定水平相关性的定性和定量描述。
结果
由于系统噪声的存在，OCTA阈值设定是形成OCTA图像的必要步骤；然而，阈值设定会使血流与OCTA信号之间的关系变得复杂。
结论
OCTA中的阈值设定可导致显著伪影，在解读和量化OCTA图像时应予以考虑。
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