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Noise-immune complex correlation for optical coherence angiography based on standard and Jones matrix optical coherence tomography.基于标准和琼斯矩阵光学相干断层扫描的光学相干血管造影的抗噪声复相关
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Methods and algorithms for optical coherence tomography-based angiography: a review and comparison.基于光学相干断层扫描血管造影的方法与算法：综述与比较
J Biomed Opt. 2015 Oct;20(10):100901. doi: 10.1117/1.JBO.20.10.100901.
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IMAGE ARTIFACTS IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.光学相干断层扫描血管造影中的图像伪影
Retina. 2015 Nov;35(11):2163-80. doi: 10.1097/IAE.0000000000000765.
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Review of speckle and phase variance optical coherence tomography to visualize microvascular networks.斑点和相位方差光相干断层扫描技术对微血管网络可视化的评价。
J Biomed Opt. 2013 May;18(5):50901. doi: 10.1117/1.JBO.18.5.050901.
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Split-spectrum amplitude-decorrelation angiography with optical coherence tomography.光学相干断层扫描的分裂谱幅度去相关血管造影术。
Opt Express. 2012 Feb 13;20(4):4710-25. doi: 10.1364/OE.20.004710.
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Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography.通过双光束扫描多普勒光学相干血管造影术对人眼进行全面的体内微血管成像。
Opt Express. 2011 Jan 17;19(2):1271-83. doi: 10.1364/OE.19.001271.
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Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment.光学微血管造影提供了后眼部定向眼血流的深度分辨图像。
J Biomed Opt. 2010 Mar-Apr;15(2):020502. doi: 10.1117/1.3353958.
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Optical coherence angiography.光学相干血管造影术。
Opt Express. 2006 Aug 21;14(17):7821-40. doi: 10.1364/oe.14.007821.
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In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography.利用光学微血管造影术对人视网膜和脉络膜内的血管灌注进行体内容积成像。
Opt Express. 2008 Jul 21;16(15):11438-52. doi: 10.1364/oe.16.011438.
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Speckle variance detection of microvasculature using swept-source optical coherence tomography.使用扫频源光学相干断层扫描技术对微血管进行散斑方差检测。
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光学相干断层扫描血管造影中阈值处理的定义、基本原理及效果

The Definition, Rationale, and Effects of Thresholding in OCT Angiography.

作者信息

Cole Emily D, Moult Eric M, Dang Sabin, Choi WooJhon, Ploner Stefan B, Lee ByungKun, Louzada Ricardo, Novais Eduardo, Schottenhamml Julia, Husvogt Lennart, Maier Andreas, Fujimoto James G, Waheed Nadia K, Duker Jay S

机构信息

New England Eye Center, Tufts Medical Center, Boston, Massachusetts.

Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.

出版信息

Ophthalmol Retina. 2017 Sep-Oct;1(5):435-447. doi: 10.1016/j.oret.2017.01.019. Epub 2017 Apr 5.

DOI:10.1016/j.oret.2017.01.019
PMID:29034359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5640169/
Abstract

PURPOSE

To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA).

DESIGN

A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series.

PARTICIPANTS

Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed.

MAIN OUTCOME MEASURES

A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level.

RESULTS

Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal.

CONCLUSIONS

Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.

摘要

目的

探讨光学相干断层扫描血管造影（OCTA）中阈值设定的定义、基本原理及效果。

设计

结合回顾性病例系列中OCTA阈值设定效果的定性和定量分析，对OCTA阈值设定进行理论描述。

参与者

对4只眼睛进行了定性检查：1只来自27岁的对照者，1只来自78岁的渗出性年龄相关性黄斑变性（AMD）患者，1只来自58岁的近视患者，1只来自77岁的非渗出性AMD伴地图样萎缩（GA）患者。对1只来自75岁的非渗出性AMD伴GA患者的眼睛进行了定量分析。

主要观察指标

一个理论阈值设定模型以及对OCTA与阈值设定水平相关性的定性和定量描述。

结果

由于系统噪声的存在，OCTA阈值设定是形成OCTA图像的必要步骤；然而，阈值设定会使血流与OCTA信号之间的关系变得复杂。

结论

OCTA中的阈值设定可导致显著伪影，在解读和量化OCTA图像时应予以考虑。