Murata Toshihiro, Miyase Toshio, Yoshizaki Fumihiko
Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Chem Pharm Bull (Tokyo). 2010 May;58(5):696-702. doi: 10.1248/cpb.58.696.
The dried whole plant of Meehania fargesii (H. LéV.) C. Y. WU is utilized as an antipyretic and antidote for poison in China. Water soluble fractions, obtained from an 80% acetone extract of the whole plant, showed hyaluronidase inhibitory activity. From these fractions, hyaluronidase inhibitors were isolated along with two new spermidine alkaloids (meefarnines A and B), four new flavone glycosides (fargenins A-D), and 10 known compounds. The structure of each was elucidated by spectroscopic methods.
在中国，狭叶龙头草（Meehania fargesii (H. LéV.) C. Y. WU）的干燥全草被用作退烧药和解毒药。从全草的80%丙酮提取物中获得的水溶性部分显示出透明质酸酶抑制活性。从这些部分中，分离出了透明质酸酶抑制剂，以及两种新的亚精胺生物碱（米法宁A和B）、四种新的黄酮苷（法尔金宁A-D）和10种已知化合物。通过光谱方法阐明了每种化合物的结构。
