van Tol E A, Elzo Kraemer C V, Verspaget H W, Masclee A A, Lamers C B
Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
Neuropeptides. 1991 Jan;18(1):15-21. doi: 10.1016/0143-4179(91)90158-f.
Peptides from both the nervous and endocrine system have been shown to influence immune functions. This study describes the stimulatory effect of bombesin on natural killer cell activity of peripheral blood mononuclear cells. The stimulation of cytotoxicity by bombesin in vivo was much higher than found in vitro. In vitro studies with bombesin and gastrin revealed that the stimulatory effect of bombesin in vivo can for a major part be attributed to other stimulatory mediators which are released by BBS. These results indicate that neuropeptide release might rapidly interfere, both directly and indirectly, with natural killer activity of peripheral blood mononuclear cells.
来自神经系统和内分泌系统的肽已被证明会影响免疫功能。本研究描述了蛙皮素对外周血单个核细胞自然杀伤细胞活性的刺激作用。蛙皮素在体内对细胞毒性的刺激作用远高于体外实验结果。对蛙皮素和胃泌素的体外研究表明，蛙皮素在体内的刺激作用在很大程度上可归因于由蛙皮素释放肽（BBS）释放的其他刺激介质。这些结果表明，神经肽的释放可能会直接或间接地迅速干扰外周血单个核细胞的自然杀伤活性。
