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Primary structure of a trisialylated oligosaccharide from human milk.

作者信息

Fievre S, Wieruszeski J M, Michalski J C, Lemoine J, Montreuil J, Strecker G

机构信息

Laboratoire de Chimie Biologique, Unité Mixte de Recherche du CNRS No 111, Villeneuve d'Ascq, France.

出版信息

Biochem Biophys Res Commun. 1991 Jun 14;177(2):720-5. doi: 10.1016/0006-291x(91)91847-6.

DOI:10.1016/0006-291x(91)91847-6
PMID:2049094
Abstract

A novel oligosaccharide has been isolated from human milk and identified as a trisialylated derivative of lacto-N-hexaose. This compound was purified by combining ion-exchange chromatography, preparative paper chromatography and high performance liquid chromatography. Structural analyses by methylation, fast atom bombardment-mass spectrometry and proton nuclear magnetic resonance spectroscopy are consistent with the following structure: formula: see text.

摘要

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引用本文的文献

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Structures and application of oligosaccharides in human milk.人乳寡糖的结构与应用。
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Structural analysis of underivatized neutral human milk oligosaccharides in the negative ion mode by nano-electrospray MS(n) (part 2: application to isomeric mixtures).
通过纳米电喷雾质谱(n)在负离子模式下对未衍生化的中性人乳寡糖进行结构分析(第2部分：应用于异构体混合物)。
J Am Soc Mass Spectrom. 2002 Nov;13(11):1341-8. doi: 10.1016/S1044-0305(02)00646-3.