活化蛋白 C 治疗 H1N1 流感？还需更多研究！
Activated protein C for H1N1 influenza? More work to do!
机构信息
Division of Infectious Disease, Rhode Island Hospital, Alpert School of Medicine, Brown University, 593 Eddy Street, Providence, RI 02903, USA.
出版信息
Crit Care. 2010;14(3):156. doi: 10.1186/cc8994. Epub 2010 May 18.
Abstract
An animal model of H1N1 influenza demonstrates that this infection is associated with pulmonary and systemic activation of coagulation and impairment of fibrinolysis in addition to systemic inflammation and intense neutrophil influx into the lung. Activated protein C attenuates coagulation activation and restores fibrinolytic capacity but has little effect on inflammation or survival from this infection. This animal model points to a profound inflammatory state developing in H1N1 infection that impacts mortality. Additional modifications to the model and the type and amount of activated protein C dosing will provide the data to determine the possible use of activated protein C as a therapy in human H1N1 infection.
摘要
甲型 H1N1 流感的动物模型表明，除了全身炎症和大量中性粒细胞涌入肺部外，这种感染还与肺部和全身的凝血激活以及纤溶功能障碍有关。活化蛋白 C 可减轻凝血激活并恢复纤溶能力，但对炎症或感染后的存活率几乎没有影响。该动物模型表明，甲型 H1N1 感染会引发严重的炎症反应，从而影响死亡率。对该模型进行进一步的改进以及改变活化蛋白 C 的类型和剂量，将提供数据以确定活化蛋白 C 作为人类甲型 H1N1 感染治疗方法的可能性。
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