Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11044-9. doi: 10.1073/pnas.1006419107. Epub 2010 Jun 1.
In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here, we describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others, must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.
在埃及，尽管在农场加强了生物安全、隔离和疫苗接种，但仍未能控制高致病性 H5N1 禽流感病毒在禽类和人类中的传播。埃及持续流行的高致病性 H5N1 禽流感已导致超过 100 人感染，仍然对兽医和公共卫生构成未解决的威胁。在这里，我们描述了在埃及，市售的 H5 禽流感疫苗的失效可能部分是由于母源 H5N1 抗体被动转移到小鸡身上，抑制了它们对疫苗接种的免疫反应。我们提出，在小鸡中，对 H5N1 的保护性免疫反应的诱导被抑制了很长一段时间。在埃及的疫情得到控制之前，必须解决这一问题以及其他问题，并采取更多措施。
