Suppr超能文献

埃及家禽中 H5N1 流感疫苗令人费解的低效率。

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry.

机构信息

Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

出版信息

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11044-9. doi: 10.1073/pnas.1006419107. Epub 2010 Jun 1.

Abstract

In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here, we describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others, must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.

摘要

在埃及,尽管在农场加强了生物安全、隔离和疫苗接种,但仍未能控制高致病性 H5N1 禽流感病毒在禽类和人类中的传播。埃及持续流行的高致病性 H5N1 禽流感已导致超过 100 人感染,仍然对兽医和公共卫生构成未解决的威胁。在这里,我们描述了在埃及,市售的 H5 禽流感疫苗的失效可能部分是由于母源 H5N1 抗体被动转移到小鸡身上,抑制了它们对疫苗接种的免疫反应。我们提出,在小鸡中,对 H5N1 的保护性免疫反应的诱导被抑制了很长一段时间。在埃及的疫情得到控制之前,必须解决这一问题以及其他问题,并采取更多措施。

相似文献

1
Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry.埃及家禽中 H5N1 流感疫苗令人费解的低效率。
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11044-9. doi: 10.1073/pnas.1006419107. Epub 2010 Jun 1.
7
Avian Influenza A(H5N1) Virus in Egypt.埃及的甲型H5N1禽流感病毒
Emerg Infect Dis. 2016 Mar;22(3):379-88. doi: 10.3201/eid2203.150593.
9
Avian influenza H5N1 vaccination efficacy in Egyptian backyard poultry.埃及后院家禽中H5N1型禽流感疫苗接种效果
Vaccine. 2017 Oct 27;35(45):6195-6201. doi: 10.1016/j.vaccine.2017.09.040. Epub 2017 Sep 25.

引用本文的文献

本文引用的文献

5
Characterization of an avian influenza virus H5N1 Egyptian isolate.一株埃及禽流感病毒H5N1分离株的特性分析
J Virol Methods. 2009 Aug;159(2):244-50. doi: 10.1016/j.jviromet.2009.04.008. Epub 2009 May 3.
6
Identification of a receptor required for the anti-inflammatory activity of IVIG.鉴定静脉注射免疫球蛋白抗炎活性所需的一种受体。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19571-8. doi: 10.1073/pnas.0810163105. Epub 2008 Nov 26.
9
Avian influenza vaccines and therapies for poultry.禽流感疫苗及家禽治疗方法。
Comp Immunol Microbiol Infect Dis. 2009 Jul;32(4):351-63. doi: 10.1016/j.cimid.2008.01.006. Epub 2008 Apr 28.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验