Zahm S H, Cocco P, Blair A
Occupational Studies Section, National Cancer Institute, Rockville, MD 20892.
Am J Public Health. 1991 Jul;81(7):846-9. doi: 10.2105/ajph.81.7.846.
Data from a cancer screening project among pattern makers were used to evaluate the association between tobacco smoking and prevalence of colon polyps.
From 1981-1983, 549 White men were examined by flexible sigmoidoscopy and completed self-administered questionnaires including smoking histories.
One or more colon polyps were detected in 76 men. Standardized prevalence rates (SPR) for polyps increased by smoking category (never smoked = 0.094; ex-smokers = 0.118, current smokers = 0.214) and by cigarettes per day, years of smoking, and pack-years among both current and ex-smokers. Both adenomatous and hyperplastic polyps showed an association with smoking while other types of polyps and polyps with unspecified histology did not. The risk associated with smoking was greater for polyps greater than one centimeter in diameter. An interaction with occupational exposures was suggested by a greater increase in the SPR for polyps among current smokers employed as pattern makers for more than 10 years than among current smokers similarly employed for 10 years or less.
Since at least some colon polyps are considered precursor lesions to colon cancer, one of the most common cancers in the United States, this report suggests that the possible link between colon polyps and smoking deserves further evaluation.
来自制模工人癌症筛查项目的数据用于评估吸烟与结肠息肉患病率之间的关联。
1981年至1983年，对549名白人男性进行了乙状结肠镜检查，并完成了包括吸烟史在内的自我管理问卷。
76名男性检测出一个或多个结肠息肉。息肉的标准化患病率（SPR）随吸烟类别增加（从不吸烟=0.094；既往吸烟者=0.118，当前吸烟者=0.214），且在当前吸烟者和既往吸烟者中均随每日吸烟量、吸烟年限和吸烟包年数增加。腺瘤性息肉和增生性息肉均与吸烟有关，而其他类型的息肉和组织学未明确的息肉则无关。直径大于1厘米的息肉与吸烟相关的风险更大。在制模工人岗位工作超过10年的当前吸烟者中，息肉的SPR增幅大于工作10年或更短时间的类似当前吸烟者，提示与职业暴露存在交互作用。
由于至少某些结肠息肉被认为是美国最常见的癌症之一结肠癌的前驱病变，本报告表明结肠息肉与吸烟之间的可能联系值得进一步评估。
