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Fabrication and functional characterization of goldnanoconjugates for potential application in ovarian cancer.用于卵巢癌潜在应用的金纳米缀合物的制备与功能表征
J Mater Chem. 2010 Jan 1;20(3):547-554. doi: 10.1039/b913224d.
2
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.载金纳米粒子提高奥沙利铂活性成分的抗癌药物传递
J Am Chem Soc. 2010 Apr 7;132(13):4678-84. doi: 10.1021/ja908117a.
3
Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers.树枝状大分子作为药物递送载体：生物活性化合物与树枝状大分子的非共价相互作用。
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4
Tamoxifen-poly(ethylene glycol)-thiol gold nanoparticle conjugates: enhanced potency and selective delivery for breast cancer treatment.他莫昔芬-聚乙二醇-巯基金纳米粒子缀合物：增强的效力和选择性递送用于乳腺癌治疗。
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5
Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.多价寡核苷酸金纳米粒子缀合物作为铂(IV)弹头的递送载体。
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6
Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity.纳米医学中的金纳米颗粒：制备、成像、诊断、治疗及毒性
Chem Soc Rev. 2009 Jun;38(6):1759-82. doi: 10.1039/b806051g. Epub 2009 Apr 21.
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9
Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines.通过捕获和释放胺的金纳米颗粒实现光调节的细胞信号激活。
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Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles.通过调节氨基酸功能化金纳米颗粒的表面电荷密度构建高效基因递送载体
ACS Nano. 2008 Nov 25;2(11):2213-8. doi: 10.1021/nn800507t.

金纳米颗粒平台作为药物和生物大分子的输送系统。

Gold nanoparticle platforms as drug and biomacromolecule delivery systems.

机构信息

Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

出版信息

J Control Release. 2010 Nov 20;148(1):122-127. doi: 10.1016/j.jconrel.2010.06.004. Epub 2010 Jun 11.

DOI:10.1016/j.jconrel.2010.06.004
PMID:20547192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2952284/
Abstract

Gold nanoparticles (AuNPs) are a suitable platform for development of efficient delivery systems. AuNPs can be easily synthesized, functionalized, and are biocompatible. The tunability of the AuNP monolayer allows for complete control of surface properties for targeting and stability/release using these nanocarriers. This review will discuss several delivery strategies utilizing AuNPs.

摘要

金纳米粒子（AuNPs）是开发高效递药系统的合适平台。AuNPs 易于合成、功能化且生物相容性好。AuNP 单层的可调变性允许使用这些纳米载体完全控制表面性质，以实现靶向和稳定性/释放。本文将讨论几种利用 AuNPs 的递药策略。